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A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.
Bramsen JB, Pakula MM, Hansen TB, Bus C, Langkjær N, Odadzic D, Smicius R, Wengel SL, Chattopadhyaya J, Engels JW, Herdewijn P, Wengel J, Kjems J. Bramsen JB, et al. Among authors: pakula mm. Nucleic Acids Res. 2010 Sep;38(17):5761-73. doi: 10.1093/nar/gkq341. Epub 2010 May 7. Nucleic Acids Res. 2010. PMID: 20453030 Free PMC article.
Tunable CD44-specific cellular retargeting with hyaluronic acid nanoshells.
Ebbesen MF, Olesen MT, Gjelstrup MC, Pakula MM, Larsen EK, Hansen IM, Hansen PL, Mollenhauer J, Malle BM, Howard KA. Ebbesen MF, et al. Among authors: pakula mm. Pharm Res. 2015 Apr;32(4):1462-74. doi: 10.1007/s11095-014-1552-7. Epub 2014 Nov 1. Pharm Res. 2015. PMID: 25361867
Could drugs inhibiting the mevalonate pathway also target cancer stem cells?
Likus W, Siemianowicz K, Bieńk K, Pakuła M, Pathak H, Dutta C, Wang Q, Shojaei S, Assaraf YG, Ghavami S, Cieślar-Pobuda A, Łos MJ. Likus W, et al. Drug Resist Updat. 2016 Mar;25:13-25. doi: 10.1016/j.drup.2016.02.001. Epub 2016 Feb 20. Drug Resist Updat. 2016. PMID: 27155373 Free article. Review.