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Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo.
Mol Biosyst. 2010 May;6(5):862-70. doi: 10.1039/b918869j. Epub 2010 Feb 9.
Mol Biosyst. 2010.
PMID: 20567772
A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.
Bramsen JB, Pakula MM, Hansen TB, Bus C, Langkjær N, Odadzic D, Smicius R, Wengel SL, Chattopadhyaya J, Engels JW, Herdewijn P, Wengel J, Kjems J.
Bramsen JB, et al. Among authors: pakula mm.
Nucleic Acids Res. 2010 Sep;38(17):5761-73. doi: 10.1093/nar/gkq341. Epub 2010 May 7.
Nucleic Acids Res. 2010.
PMID: 20453030
Free PMC article.
Item in Clipboard
In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important.
Schyth BD, Bramsen JB, Pakula MM, Larashati S, Kjems J, Wengel J, Lorenzen N.
Schyth BD, et al. Among authors: pakula mm.
Nucleic Acids Res. 2012 May;40(10):4653-65. doi: 10.1093/nar/gks033. Epub 2012 Jan 28.
Nucleic Acids Res. 2012.
PMID: 22287630
Free PMC article.
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An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing.
Bienk K, Hvam ML, Pakula MM, Dagnæs-Hansen F, Wengel J, Malle BM, Kragh-Hansen U, Cameron J, Bukrinski JT, Howard KA.
Bienk K, et al. Among authors: pakula mm.
J Control Release. 2016 Jun 28;232:143-51. doi: 10.1016/j.jconrel.2016.04.013. Epub 2016 Apr 12.
J Control Release. 2016.
PMID: 27084489
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Tunable CD44-specific cellular retargeting with hyaluronic acid nanoshells.
Ebbesen MF, Olesen MT, Gjelstrup MC, Pakula MM, Larsen EK, Hansen IM, Hansen PL, Mollenhauer J, Malle BM, Howard KA.
Ebbesen MF, et al. Among authors: pakula mm.
Pharm Res. 2015 Apr;32(4):1462-74. doi: 10.1007/s11095-014-1552-7. Epub 2014 Nov 1.
Pharm Res. 2015.
PMID: 25361867
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Could drugs inhibiting the mevalonate pathway also target cancer stem cells?
Likus W, Siemianowicz K, Bieńk K, Pakuła M, Pathak H, Dutta C, Wang Q, Shojaei S, Assaraf YG, Ghavami S, Cieślar-Pobuda A, Łos MJ.
Likus W, et al.
Drug Resist Updat. 2016 Mar;25:13-25. doi: 10.1016/j.drup.2016.02.001. Epub 2016 Feb 20.
Drug Resist Updat. 2016.
PMID: 27155373
Free article.
Review.
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Insight on the impacts of free amino acids and their metabolites on the immune system from a perspective of inborn errors of amino acid metabolism.
Pakula MM, Maier TJ, Vorup-Jensen T.
Pakula MM, et al.
Expert Opin Ther Targets. 2017 Jun;21(6):611-626. doi: 10.1080/14728222.2017.1323879. Epub 2017 May 9.
Expert Opin Ther Targets. 2017.
PMID: 28441889
Review.
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