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Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer.
Junutula JR, Flagella KM, Graham RA, Parsons KL, Ha E, Raab H, Bhakta S, Nguyen T, Dugger DL, Li G, Mai E, Lewis Phillips GD, Hiraragi H, Fuji RN, Tibbitts J, Vandlen R, Spencer SD, Scheller RH, Polakis P, Sliwkowski MX. Junutula JR, et al. Clin Cancer Res. 2010 Oct 1;16(19):4769-78. doi: 10.1158/1078-0432.CCR-10-0987. Epub 2010 Aug 30. Clin Cancer Res. 2010. PMID: 20805300
The RCP-Rab11 complex regulates endocytic protein sorting.
Peden AA, Schonteich E, Chun J, Junutula JR, Scheller RH, Prekeris R. Peden AA, et al. Among authors: junutula jr. Mol Biol Cell. 2004 Aug;15(8):3530-41. doi: 10.1091/mbc.e03-12-0918. Epub 2004 Jun 4. Mol Biol Cell. 2004. PMID: 15181150 Free PMC article.
Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene.
Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG. Westlake CJ, et al. Among authors: junutula jr. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1236-41. doi: 10.1073/pnas.0610500104. Epub 2007 Jan 17. Proc Natl Acad Sci U S A. 2007. PMID: 17229837 Free PMC article.
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.
Junutula JR, Raab H, Clark S, Bhakta S, Leipold DD, Weir S, Chen Y, Simpson M, Tsai SP, Dennis MS, Lu Y, Meng YG, Ng C, Yang J, Lee CC, Duenas E, Gorrell J, Katta V, Kim A, McDorman K, Flagella K, Venook R, Ross S, Spencer SD, Lee Wong W, Lowman HB, Vandlen R, Sliwkowski MX, Scheller RH, Polakis P, Mallet W. Junutula JR, et al. Nat Biotechnol. 2008 Aug;26(8):925-32. doi: 10.1038/nbt.1480. Epub 2008 Jul 20. Nat Biotechnol. 2008. PMID: 18641636
Site-specifically 89Zr-labeled monoclonal antibodies for ImmunoPET.
Tinianow JN, Gill HS, Ogasawara A, Flores JE, Vanderbilt AN, Luis E, Vandlen R, Darwish M, Junutula JR, Williams SP, Marik J. Tinianow JN, et al. Among authors: junutula jr. Nucl Med Biol. 2010 Apr;37(3):289-97. doi: 10.1016/j.nucmedbio.2009.11.010. Epub 2010 Feb 10. Nucl Med Biol. 2010. PMID: 20346868
48 results