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Identification of seventeen new simian immunodeficiency virus-derived CD8+ T cell epitopes restricted by the high frequency molecule, Mamu-A*02, and potential escape from CTL recognition.
Loffredo JT, Sidney J, Wojewoda C, Dodds E, Reynolds MR, Napoé G, Mothé BR, O'Connor DH, Wilson NA, Watkins DI, Sette A. Loffredo JT, et al. Among authors: watkins di. J Immunol. 2004 Oct 15;173(8):5064-76. doi: 10.4049/jimmunol.173.8.5064. J Immunol. 2004. PMID: 15470050
The high frequency Indian rhesus macaque MHC class I molecule, Mamu-B*01, does not appear to be involved in CD8+ T lymphocyte responses to SIVmac239.
Loffredo JT, Sidney J, Piaskowski S, Szymanski A, Furlott J, Rudersdorf R, Reed J, Peters B, Hickman-Miller HD, Bardet W, Rehrauer WM, O'Connor DH, Wilson NA, Hildebrand WH, Sette A, Watkins DI. Loffredo JT, et al. Among authors: watkins di. J Immunol. 2005 Nov 1;175(9):5986-97. doi: 10.4049/jimmunol.175.9.5986. J Immunol. 2005. PMID: 16237093
Tat(28-35)SL8-specific CD8+ T lymphocytes are more effective than Gag(181-189)CM9-specific CD8+ T lymphocytes at suppressing simian immunodeficiency virus replication in a functional in vitro assay.
Loffredo JT, Rakasz EG, Giraldo JP, Spencer SP, Grafton KK, Martin SR, Napoé G, Yant LJ, Wilson NA, Watkins DI. Loffredo JT, et al. Among authors: watkins di. J Virol. 2005 Dec;79(23):14986-91. doi: 10.1128/JVI.79.23.14986-14991.2005. J Virol. 2005. PMID: 16282500 Free PMC article.
The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape.
Loffredo JT, Burwitz BJ, Rakasz EG, Spencer SP, Stephany JJ, Vela JP, Martin SR, Reed J, Piaskowski SM, Furlott J, Weisgrau KL, Rodrigues DS, Soma T, Napoé G, Friedrich TC, Wilson NA, Kallas EG, Watkins DI. Loffredo JT, et al. Among authors: watkins di. J Virol. 2007 Mar;81(6):2624-34. doi: 10.1128/JVI.01912-06. Epub 2006 Dec 27. J Virol. 2007. PMID: 17192314 Free PMC article.
Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression.
Sacha JB, Chung C, Rakasz EG, Spencer SP, Jonas AK, Bean AT, Lee W, Burwitz BJ, Stephany JJ, Loffredo JT, Allison DB, Adnan S, Hoji A, Wilson NA, Friedrich TC, Lifson JD, Yang OO, Watkins DI. Sacha JB, et al. Among authors: watkins di. J Immunol. 2007 Mar 1;178(5):2746-54. doi: 10.4049/jimmunol.178.5.2746. J Immunol. 2007. PMID: 17312117 Free PMC article.
Mamu-B*08-positive macaques control simian immunodeficiency virus replication.
Loffredo JT, Maxwell J, Qi Y, Glidden CE, Borchardt GJ, Soma T, Bean AT, Beal DR, Wilson NA, Rehrauer WM, Lifson JD, Carrington M, Watkins DI. Loffredo JT, et al. Among authors: watkins di. J Virol. 2007 Aug;81(16):8827-32. doi: 10.1128/JVI.00895-07. Epub 2007 May 30. J Virol. 2007. PMID: 17537848 Free PMC article.
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