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Page 1
Selective inhibition of BET bromodomains.
Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE. Filippakopoulos P, et al. Among authors: morse em. Nature. 2010 Dec 23;468(7327):1067-73. doi: 10.1038/nature09504. Epub 2010 Sep 24. Nature. 2010. PMID: 20871596 Free PMC article.
A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.
Kemp MM, Wang Q, Fuller JH, West N, Martinez NM, Morse EM, Weïwer M, Schreiber SL, Bradner JE, Koehler AN. Kemp MM, et al. Among authors: morse em. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4164-9. doi: 10.1016/j.bmcl.2011.05.098. Epub 2011 Jun 2. Bioorg Med Chem Lett. 2011. PMID: 21696956 Free PMC article.
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.
Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL. Bradner JE, et al. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12617-22. doi: 10.1073/pnas.1006774107. Epub 2010 Jun 28. Proc Natl Acad Sci U S A. 2010. PMID: 20616024 Free PMC article.
Defining the role of syndecan-4 in mechanotransduction using surface-modification approaches.
Bellin RM, Kubicek JD, Frigault MJ, Kamien AJ, Steward RL Jr, Barnes HM, Digiacomo MB, Duncan LJ, Edgerly CK, Morse EM, Park CY, Fredberg JJ, Cheng CM, LeDuc PR. Bellin RM, et al. Among authors: morse em. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22102-7. doi: 10.1073/pnas.0902639106. Epub 2009 Dec 22. Proc Natl Acad Sci U S A. 2009. PMID: 20080785 Free PMC article.
Integrin cytoplasmic tail interactions.
Morse EM, Brahme NN, Calderwood DA. Morse EM, et al. Biochemistry. 2014 Feb 11;53(5):810-20. doi: 10.1021/bi401596q. Epub 2014 Jan 27. Biochemistry. 2014. PMID: 24467163 Free PMC article. Review.
Zasp regulates integrin activation.
Bouaouina M, Jani K, Long JY, Czerniecki S, Morse EM, Ellis SJ, Tanentzapf G, Schöck F, Calderwood DA. Bouaouina M, et al. Among authors: morse em. J Cell Sci. 2012 Dec 1;125(Pt 23):5647-57. doi: 10.1242/jcs.103291. Epub 2012 Sep 19. J Cell Sci. 2012. PMID: 22992465 Free PMC article.
16 results