An attenuating mutation in nsP1 of the Sindbis-group virus S.A.AR86 accelerates nonstructural protein processing and up-regulates viral 26S RNA synthesis.
Heise MT, White LJ, Simpson DA, Leonard C, Bernard KA, Meeker RB, Johnston RE.
Heise MT, et al.
J Virol. 2003 Jan;77(2):1149-56. doi: 10.1128/jvi.77.2.1149-1156.2003.
J Virol. 2003.
PMID: 12502831
Free PMC article.
Mutation of the nsP1 538 Thr to the consensus Ile found in nonneurovirulent Sindbis-group alphaviruses attenuates S.A.AR86 for adult mouse neurovirulence, while introduction of Thr at position 538 in a nonneurovirulent Sindbis virus background confers increased neurovirulence ( …
Mutation of the nsP1 538 Thr to the consensus Ile found in nonneurovirulent Sindbis-group alphaviruses attenuates S.A.AR86 for adult mouse n …