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Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK.
Tanis SP, Plewe MB, Johnson TW, Butler SL, Dalvie D, DeLisle D, Dress KR, Hu Q, Huang B, Kuehler JE, Kuki A, Liu W, Peng Q, Smith GL, Solowiej J, Tran KT, Wang H, Yang A, Yin C, Yu X, Zhang J, Zhu H. Tanis SP, et al. Among authors: butler sl. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7429-34. doi: 10.1016/j.bmcl.2010.10.022. Epub 2010 Oct 13. Bioorg Med Chem Lett. 2010. PMID: 21036042
Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors.
Plewe MB, Butler SL, Dress KR, Hu Q, Johnson TW, Kuehler JE, Kuki A, Lam H, Liu W, Nowlin D, Peng Q, Rahavendran SV, Tanis SP, Tran KT, Wang H, Yang A, Zhang J. Plewe MB, et al. Among authors: butler sl. J Med Chem. 2009 Nov 26;52(22):7211-9. doi: 10.1021/jm900862n. J Med Chem. 2009. PMID: 19873974
Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors.
Johnson TW, Tanis SP, Butler SL, Dalvie D, Delisle DM, Dress KR, Flahive EJ, Hu Q, Kuehler JE, Kuki A, Liu W, McClellan GA, Peng Q, Plewe MB, Richardson PF, Smith GL, Solowiej J, Tran KT, Wang H, Yu X, Zhang J, Zhu H. Johnson TW, et al. Among authors: butler sl. J Med Chem. 2011 May 12;54(9):3393-417. doi: 10.1021/jm200208d. Epub 2011 Apr 13. J Med Chem. 2011. PMID: 21446745
Identification and characterization of UK-201844, a novel inhibitor that interferes with human immunodeficiency virus type 1 gp160 processing.
Blair WS, Cao J, Jackson L, Jimenez J, Peng Q, Wu H, Isaacson J, Butler SL, Chu A, Graham J, Malfait AM, Tortorella M, Patick AK. Blair WS, et al. Among authors: butler sl. Antimicrob Agents Chemother. 2007 Oct;51(10):3554-61. doi: 10.1128/AAC.00643-07. Epub 2007 Jul 23. Antimicrob Agents Chemother. 2007. PMID: 17646410 Free PMC article.
HIV capsid is a tractable target for small molecule therapeutic intervention.
Blair WS, Pickford C, Irving SL, Brown DG, Anderson M, Bazin R, Cao J, Ciaramella G, Isaacson J, Jackson L, Hunt R, Kjerrstrom A, Nieman JA, Patick AK, Perros M, Scott AD, Whitby K, Wu H, Butler SL. Blair WS, et al. Among authors: butler sl. PLoS Pathog. 2010 Dec 9;6(12):e1001220. doi: 10.1371/journal.ppat.1001220. PLoS Pathog. 2010. PMID: 21170360 Free PMC article.
59 results