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Identification of novel pyrrolopyrazoles as protein kinase C β II inhibitors.
Li H, Hong Y, Nukui S, Lou J, Johnson S, Scales S, Botrous I, Tompkins E, Yin C, Zhou R, He M, Jensen J, Bouzida D, Alton G, Lafontaine J, Grant S. Li H, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):584-7. doi: 10.1016/j.bmcl.2010.10.032. Epub 2010 Oct 13. Bioorg Med Chem Lett. 2011. PMID: 21084194
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
Li H, Tatlock J, Linton A, Gonzalez J, Jewell T, Patel L, Ludlum S, Drowns M, Rahavendran SV, Skor H, Hunter R, Shi ST, Herlihy KJ, Parge H, Hickey M, Yu X, Chau F, Nonomiya J, Lewis C. Li H, et al. J Med Chem. 2009 Mar 12;52(5):1255-8. doi: 10.1021/jm8014537. J Med Chem. 2009. PMID: 19209845
Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat model.
Grant S, Tran P, Zhang Q, Zou A, Dinh D, Jensen J, Zhou S, Kang X, Zachwieja J, Lippincott J, Liu K, Johnson SL, Scales S, Yin C, Nukui S, Stoner C, Prasanna G, Lafontaine J, Wells P, Li H. Grant S, et al. Among authors: li h. Eur J Pharmacol. 2010 Feb 10;627(1-3):16-25. doi: 10.1016/j.ejphar.2009.10.029. Epub 2009 Oct 20. Eur J Pharmacol. 2010. PMID: 19850035
Application of cultured human mast cells (CHMC) for the design and structure-activity relationship of IgE-mediated mast cell activation inhibitors.
Argade A, Bhamidipati S, Li H, Carroll D, Clough J, Keim H, Sylvain C, Rossi AB, Coquilla C, Issakani SD, Masuda ES, Payan DG, Singh R. Argade A, et al. Among authors: li h. Bioorg Med Chem Lett. 2015;25(10):2117-21. doi: 10.1016/j.bmcl.2015.03.075. Epub 2015 Mar 31. Bioorg Med Chem Lett. 2015. PMID: 25872982
Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling.
Argade A, Bhamidipati S, Li H, Sylvain C, Clough J, Carroll D, Keim H, Braselmann S, Taylor V, Zhao H, Herlaar E, Issakani SD, Wong BR, Masuda ES, Payan DG, Singh R. Argade A, et al. Among authors: li h. Bioorg Med Chem Lett. 2015;25(10):2122-8. doi: 10.1016/j.bmcl.2015.03.072. Epub 2015 Apr 1. Bioorg Med Chem Lett. 2015. PMID: 25891105
Bicyclic pyrimidine compounds as potent IRAK4 inhibitors.
Chen Y, Tso K, Heckrodt TJ, Li H, Yen R, Lin N, Singh R, Taylor V, Masuda ES, Park G, Payan DG. Chen Y, et al. Among authors: li h. Bioorg Med Chem Lett. 2022 Oct 1;73:128900. doi: 10.1016/j.bmcl.2022.128900. Epub 2022 Jul 18. Bioorg Med Chem Lett. 2022. PMID: 35863718
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