Nazarian R - Search Results

1

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.

Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS. Nazarian R, et al. Nature. 2010 Dec 16;468(7326):973-7. doi: 10.1038/nature09626. Epub 2010 Nov 24. Nature. 2010. PMID: 21107323 Free PMC article.

2

Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032.

Søndergaard JN, Nazarian R, Wang Q, Guo D, Hsueh T, Mok S, Sazegar H, MacConaill LE, Barretina JG, Kehoe SM, Attar N, von Euw E, Zuckerman JE, Chmielowski B, Comin-Anduix B, Koya RC, Mischel PS, Lo RS, Ribas A. Søndergaard JN, et al. Among authors: nazarian r. J Transl Med. 2010 Apr 20;8:39. doi: 10.1186/1479-5876-8-39. J Transl Med. 2010. PMID: 20406486 Free PMC article.

3

Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors.

Shi H, Moriceau G, Kong X, Koya RC, Nazarian R, Pupo GM, Bacchiocchi A, Dahlman KB, Chmielowski B, Sosman JA, Halaban R, Kefford RF, Long GV, Ribas A, Lo RS. Shi H, et al. Among authors: nazarian r. Cancer Discov. 2012 May;2(5):414-24. doi: 10.1158/2159-8290.CD-12-0022. Epub 2012 Apr 1. Cancer Discov. 2012. PMID: 22588879 Free PMC article.

4

Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway.

Atefi M, von Euw E, Attar N, Ng C, Chu C, Guo D, Nazarian R, Chmielowski B, Glaspy JA, Comin-Anduix B, Mischel PS, Lo RS, Ribas A. Atefi M, et al. Among authors: nazarian r. PLoS One. 2011;6(12):e28973. doi: 10.1371/journal.pone.0028973. Epub 2011 Dec 14. PLoS One. 2011. PMID: 22194965 Free PMC article.

5

Rescue of cell cycle progression in BRAF^V600E inhibitor-resistant human melanoma by a chromatin modifier.

Toress-Collado AX, Nazarian R, Jazirehi AR. Toress-Collado AX, et al. Among authors: nazarian r. Tumour Biol. 2017 Sep;39(9):1010428317721620. doi: 10.1177/1010428317721620. Tumour Biol. 2017. PMID: 28936920 Free article.

6

MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer.

Nickols NG, Nazarian R, Zhao SG, Tan V, Uzunangelov V, Xia Z, Baertsch R, Neeman E, Gao AC, Thomas GV, Howard L, De Hoedt AM, Stuart J, Goldstein T, Chi K, Gleave ME, Graff JN, Beer TM, Drake JM, Evans CP, Aggarwal R, Foye A, Feng FY, Small EJ, Aronson WJ, Freedland SJ, Witte ON, Huang J, Alumkal JJ, Reiter RE, Rettig MB. Nickols NG, et al. Among authors: nazarian r. Prostate Cancer Prostatic Dis. 2019 Dec;22(4):531-538. doi: 10.1038/s41391-019-0134-5. Epub 2019 Feb 25. Prostate Cancer Prostatic Dis. 2019. PMID: 30804427 Free PMC article.

7

Aberrant apoptotic machinery confers melanoma dual resistance to BRAF(V600E) inhibitor and immune effector cells: immunosensitization by a histone deacetylase inhibitor.

Jazirehi AR, Nazarian R, Torres-Collado AX, Economou JS. Jazirehi AR, et al. Among authors: nazarian r. Am J Clin Exp Immunol. 2014 Feb 27;3(1):43-56. eCollection 2014. Am J Clin Exp Immunol. 2014. PMID: 24660121 Free PMC article.

8

Ciliary neurotrophic factor activates JAK/Stat signal transduction cascade and induces transcriptional expression of glial fibrillary acidic protein in glial cells.

Kahn MA, Huang CJ, Caruso A, Barresi V, Nazarian R, Condorelli DF, de Vellis J. Kahn MA, et al. Among authors: nazarian r. J Neurochem. 1997 Apr;68(4):1413-23. doi: 10.1046/j.1471-4159.1997.68041413.x. J Neurochem. 1997. PMID: 9084411 Free article.

9

The ATP-stimulated translocation promoter (ASTP) activity of glycerol kinase plays central role in adipogenesis.

Parr LS, Sriram G, Nazarian R, Rahib L, Dipple KM. Parr LS, et al. Among authors: nazarian r. Mol Genet Metab. 2018 Aug;124(4):254-265. doi: 10.1016/j.ymgme.2018.06.001. Epub 2018 Jun 12. Mol Genet Metab. 2018. PMID: 29960856

10

Epigenomics and targeted therapy in cancer.

Nazarian R, Jazirehi AR. Nazarian R, et al. Epigenomics. 2014;6(6):571-5. doi: 10.2217/epi.14.72. Epigenomics. 2014. PMID: 25531250 No abstract available.

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