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Low level of the K103N HIV-1 above a threshold is associated with virological failure in treatment-naive individuals undergoing efavirenz-containing therapy.
AIDS. 2011 Jan 28;25(3):325-33. doi: 10.1097/QAD.0b013e3283427dcb.
AIDS. 2011.
PMID: 21157296
Clinical Trial.
Low-level K65R mutation in HIV-1 reverse transcriptase of treatment-experienced patients exposed to abacavir or didanosine.
Svarovskaia ES, Margot NA, Bae AS, Waters JM, Goodman D, Zhong L, Borroto-Esoda K, Miller MD.
Svarovskaia ES, et al.
J Acquir Immune Defic Syndr. 2007 Oct 1;46(2):174-80. doi: 10.1097/QAI.0b013e31814258c0.
J Acquir Immune Defic Syndr. 2007.
PMID: 17667333
Clinical Trial.
Item in Clipboard
The A62V and S68G mutations in HIV-1 reverse transcriptase partially restore the replication defect associated with the K65R mutation.
Svarovskaia ES, Feng JY, Margot NA, Myrick F, Goodman D, Ly JK, White KL, Kutty N, Wang R, Borroto-Esoda K, Miller MD.
Svarovskaia ES, et al.
J Acquir Immune Defic Syndr. 2008 Aug 1;48(4):428-36. doi: 10.1097/QAI.0b013e31817bbe93.
J Acquir Immune Defic Syndr. 2008.
PMID: 18614922
Item in Clipboard
The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study.
Feng JY, Ly JK, Myrick F, Goodman D, White KL, Svarovskaia ES, Borroto-Esoda K, Miller MD.
Feng JY, et al.
Retrovirology. 2009 May 13;6:44. doi: 10.1186/1742-4690-6-44.
Retrovirology. 2009.
PMID: 19439089
Free PMC article.
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Impact of primary elvitegravir resistance-associated mutations in HIV-1 integrase on drug susceptibility and viral replication fitness.
Abram ME, Hluhanich RM, Goodman DD, Andreatta KN, Margot NA, Ye L, Niedziela-Majka A, Barnes TL, Novikov N, Chen X, Svarovskaia ES, McColl DJ, White KL, Miller MD.
Abram ME, et al. Among authors: goodman dd.
Antimicrob Agents Chemother. 2013 Jun;57(6):2654-63. doi: 10.1128/AAC.02568-12. Epub 2013 Mar 25.
Antimicrob Agents Chemother. 2013.
PMID: 23529738
Free PMC article.
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Reduced viral fitness and lack of cross-class resistance with integrase strand transfer inhibitor and nucleoside reverse transcriptase inhibitor resistance mutations.
Andreatta KN, Goodman DD, Miller MD, White KL.
Andreatta KN, et al. Among authors: goodman dd.
Antimicrob Agents Chemother. 2015;59(6):3441-9. doi: 10.1128/AAC.00040-15. Epub 2015 Mar 30.
Antimicrob Agents Chemother. 2015.
PMID: 25824231
Free PMC article.
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