High KA - Search Results

1

Adeno-associated virus vectors serotype 2 induce prolonged proliferation of capsid-specific CD8+ T cells in mice.

Li H, Tuyishime S, Wu TL, Giles-Davis W, Zhou D, Xiao W, High KA, Ertl HC. Li H, et al. Among authors: high ka. Mol Ther. 2011 Mar;19(3):536-46. doi: 10.1038/mt.2010.267. Epub 2010 Dec 14. Mol Ther. 2011. PMID: 21157435 Free PMC article.

2

Identification of mouse AAV capsid-specific CD8+ T cell epitopes.

Sabatino DE, Mingozzi F, Hui DJ, Chen H, Colosi P, Ertl HC, High KA. Sabatino DE, et al. Among authors: high ka. Mol Ther. 2005 Dec;12(6):1023-33. doi: 10.1016/j.ymthe.2005.09.009. Epub 2005 Nov 2. Mol Ther. 2005. PMID: 16263332 Free article.

3

Pre-existing AAV capsid-specific CD8+ T cells are unable to eliminate AAV-transduced hepatocytes.

Li H, Murphy SL, Giles-Davis W, Edmonson S, Xiang Z, Li Y, Lasaro MO, High KA, Ertl HC. Li H, et al. Among authors: high ka. Mol Ther. 2007 Apr;15(4):792-800. doi: 10.1038/sj.mt.6300090. Epub 2007 Jan 23. Mol Ther. 2007. PMID: 17245353 Free article.

4

CD8(+) T-cell responses to adeno-associated virus capsid in humans.

Mingozzi F, Maus MV, Hui DJ, Sabatino DE, Murphy SL, Rasko JE, Ragni MV, Manno CS, Sommer J, Jiang H, Pierce GF, Ertl HC, High KA. Mingozzi F, et al. Among authors: high ka. Nat Med. 2007 Apr;13(4):419-22. doi: 10.1038/nm1549. Epub 2007 Mar 18. Nat Med. 2007. PMID: 17369837

5

A preclinical animal model to assess the effect of pre-existing immunity on AAV-mediated gene transfer.

Li H, Lin SW, Giles-Davis W, Li Y, Zhou D, Xiang ZQ, High KA, Ertl HC. Li H, et al. Among authors: high ka. Mol Ther. 2009 Jul;17(7):1215-24. doi: 10.1038/mt.2009.79. Epub 2009 Apr 14. Mol Ther. 2009. PMID: 19367258 Free PMC article.

6

Capsid-specific T-cell responses to natural infections with adeno-associated viruses in humans differ from those of nonhuman primates.

Li H, Lasaro MO, Jia B, Lin SW, Haut LH, High KA, Ertl HC. Li H, et al. Among authors: high ka. Mol Ther. 2011 Nov;19(11):2021-30. doi: 10.1038/mt.2011.81. Epub 2011 May 17. Mol Ther. 2011. PMID: 21587208 Free PMC article.

7

Self-complementary AAVs induce more potent transgene product-specific immune responses compared to a single-stranded genome.

Wu T, Töpfer K, Lin SW, Li H, Bian A, Zhou XY, High KA, Ertl HC. Wu T, et al. Among authors: high ka. Mol Ther. 2012 Mar;20(3):572-9. doi: 10.1038/mt.2011.280. Epub 2011 Dec 20. Mol Ther. 2012. PMID: 22186792 Free PMC article.

8

Effects of immunosuppression on circulating adeno-associated virus capsid-specific T cells in humans.

Parzych EM, Li H, Yin X, Liu Q, Wu TL, Podsakoff GM, High KA, Levine MH, Ertl HC. Parzych EM, et al. Among authors: high ka. Hum Gene Ther. 2013 Apr;24(4):431-42. doi: 10.1089/hum.2012.246. Hum Gene Ther. 2013. PMID: 23461589 Free PMC article.

9

CD8+ T cell recognition of epitopes within the capsid of adeno-associated virus 8-based gene transfer vectors depends on vectors' genome.

Wu TL, Li H, Faust SM, Chi E, Zhou S, Wright F, High KA, Ertl HC. Wu TL, et al. Among authors: high ka. Mol Ther. 2014 Jan;22(1):42-51. doi: 10.1038/mt.2013.218. Epub 2013 Sep 30. Mol Ther. 2014. PMID: 24077034 Free PMC article.

10

Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid.

Vercauteren K, Hoffman BE, Zolotukhin I, Keeler GD, Xiao JW, Basner-Tschakarjan E, High KA, Ertl HC, Rice CM, Srivastava A, de Jong YP, Herzog RW. Vercauteren K, et al. Among authors: high ka. Mol Ther. 2016 Jun;24(6):1042-1049. doi: 10.1038/mt.2016.61. Epub 2016 Mar 29. Mol Ther. 2016. PMID: 27019999 Free PMC article.

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