Hawkinson J - Search Results

1

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.

Basi GS, Hemphill S, Brigham EF, Liao A, Aubele DL, Baker J, Barbour R, Bova M, Chen XH, Dappen MS, Eichenbaum T, Goldbach E, Hawkinson J, Lawler-Herbold R, Hu K, Hui T, Jagodzinski JJ, Keim PS, Kholodenko D, Latimer LH, Lee M, Marugg J, Mattson MN, McCauley S, Miller JL, Motter R, Mutter L, Neitzel ML, Ni H, Nguyen L, Quinn K, Ruslim L, Semko CM, Shapiro P, Smith J, Soriano F, Szoke B, Tanaka K, Tang P, Tucker JA, Ye XM, Yu M, Wu J, Xu YZ, Garofalo AW, Sauer JM, Konradi AW, Ness D, Shopp G, Pleiss MA, Freedman SB, Schenk D. Basi GS, et al. Among authors: hawkinson j. Alzheimers Res Ther. 2010 Dec 29;2(6):36. doi: 10.1186/alzrt60. Alzheimers Res Ther. 2010. PMID: 21190552 Free PMC article.

2

Preparation and optimization of a series of 3-carboxamido-5-phenacylaminopyrazole bradykinin B1 receptor antagonists.

Dressen D, Garofalo AW, Hawkinson J, Hom D, Jagodzinski J, Marugg JL, Neitzel ML, Pleiss MA, Szoke B, Tung JS, Wone DW, Wu J, Zhang H. Dressen D, et al. Among authors: hawkinson j. J Med Chem. 2007 Oct 18;50(21):5161-7. doi: 10.1021/jm051292n. Epub 2007 Sep 19. J Med Chem. 2007. PMID: 17880055

3

Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.

Hawkinson JE, Szoke BG, Garofalo AW, Hom DS, Zhang H, Dreyer M, Fukuda JY, Chen L, Samant B, Simmonds S, Zeitz KP, Wadsworth A, Liao A, Chavez RA, Zmolek W, Ruslim L, Bova MP, Holcomb R, Butelman ER, Ko MC, Malmberg AB. Hawkinson JE, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):619-30. doi: 10.1124/jpet.107.120352. Epub 2007 Apr 30. J Pharmacol Exp Ther. 2007. PMID: 17470643

4

Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(arylalkynyl)-4-benzylpiperidines.

Wright JL, Gregory TF, Bigge CF, Boxer PA, Serpa K, Meltzer LT, Wise LD, Cai SX, Hawkinson JE, Konkoy CS, Whittemore ER, Woodward RM, Zhou ZL. Wright JL, et al. Among authors: hawkinson je. J Med Chem. 1999 Jul 1;42(13):2469-77. doi: 10.1021/jm990148x. J Med Chem. 1999. PMID: 10395488

5

Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site.

Cai SX, Zhou ZL, Huang JC, Whittemore ER, Egbuwoku ZO, Lü Y, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: hawkinson je. J Med Chem. 1996 Aug 16;39(17):3248-55. doi: 10.1021/jm960214k. J Med Chem. 1996. PMID: 8765507

6

Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites.

Guzikowski AP, Cai SX, Espitia SA, Hawkinson JE, Huettner JE, Nogales DF, Tran M, Woodward RM, Weber E, Keana JF. Guzikowski AP, et al. Among authors: hawkinson je. J Med Chem. 1996 Nov 8;39(23):4643-53. doi: 10.1021/jm960479z. J Med Chem. 1996. PMID: 8917653

7

Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.

Cai SX, Kher SM, Zhou ZL, Ilyin V, Espitia SA, Tran M, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: hawkinson je. J Med Chem. 1997 Feb 28;40(5):730-8. doi: 10.1021/jm960654b. J Med Chem. 1997. PMID: 9057859

8

Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (+/-)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype.

Guzikowski AP, Tamiz AP, Acosta-Burruel M, Hong-Bae S, Cai SX, Hawkinson JE, Keana JF, Kesten SR, Shipp CT, Tran M, Whittemore ER, Woodward RM, Wright JL, Zhou ZL. Guzikowski AP, et al. Among authors: hawkinson je. J Med Chem. 2000 Mar 9;43(5):984-94. doi: 10.1021/jm990428c. J Med Chem. 2000. PMID: 10715162

9

4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist.

Zhou ZL, Cai SX, Whittemore ER, Konkoy CS, Espitia SA, Tran M, Rock DM, Coughenour LL, Hawkinson JE, Boxer PA, Bigge CF, Wise LD, Weber E, Woodward RM, Keana JF. Zhou ZL, et al. Among authors: hawkinson je. J Med Chem. 1999 Jul 29;42(15):2993-3000. doi: 10.1021/jm990246i. J Med Chem. 1999. PMID: 10425109

10

Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonists.

Zhou ZL, Navratil JM, Cai SX, Whittemore ER, Espitia SA, Hawkinson JE, Tran M, Woodward RM, Weber E, Keana JF. Zhou ZL, et al. Among authors: hawkinson je. Bioorg Med Chem. 2001 Aug;9(8):2061-71. doi: 10.1016/s0968-0896(01)00115-8. Bioorg Med Chem. 2001. PMID: 11504642

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