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Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood.
Raue A, Kreutz C, Maiwald T, Bachmann J, Schilling M, Klingmüller U, Timmer J. Raue A, et al. Bioinformatics. 2009 Aug 1;25(15):1923-9. doi: 10.1093/bioinformatics/btp358. Epub 2009 Jun 8. Bioinformatics. 2009. PMID: 19505944
Often only parts of the model can be observed directly. Given a model that sufficiently describes the measured data, it is important to infer how well model parameters are determined by the amount and quality of experimental data. This knowledge is essential for further in …
Often only parts of the model can be observed directly. Given a model that sufficiently describes the measured data, it is important …
Profile likelihood in systems biology.
Kreutz C, Raue A, Kaschek D, Timmer J. Kreutz C, et al. Among authors: raue a. FEBS J. 2013 Jun;280(11):2564-71. doi: 10.1111/febs.12276. Epub 2013 May 9. FEBS J. 2013. PMID: 23581573 Free article. Review.
Lessons learned from quantitative dynamical modeling in systems biology.
Raue A, Schilling M, Bachmann J, Matteson A, Schelker M, Kaschek D, Hug S, Kreutz C, Harms BD, Theis FJ, Klingmüller U, Timmer J. Raue A, et al. PLoS One. 2013 Sep 30;8(9):e74335. doi: 10.1371/journal.pone.0074335. eCollection 2013. PLoS One. 2013. PMID: 24098642 Free PMC article.
Comparison of approaches for parameter identifiability analysis of biological systems.
Raue A, Karlsson J, Saccomani MP, Jirstrand M, Timmer J. Raue A, et al. Bioinformatics. 2014 May 15;30(10):1440-8. doi: 10.1093/bioinformatics/btu006. Epub 2014 Jan 23. Bioinformatics. 2014. PMID: 24463185
In this setting, the model parameters may not be uniquely determinable. Structural or a priori identifiability is a property of the system equations that indicates whether, in principle, the unknown model parameters can be determined from the available data. RESULTS …
In this setting, the model parameters may not be uniquely determinable. Structural or a priori identifiability is a property o …
37 results