Jakobsson PJ - Search Results

1

Prostaglandin E2 synthesizing enzymes in rheumatoid arthritis B cells and the effects of B cell depleting therapy on enzyme expression.

Gheorghe KR, Thurlings RM, Westman M, Boumans MJ, Malmström V, Trollmo C, Korotkova M, Jakobsson PJ, Tak PP. Gheorghe KR, et al. Among authors: jakobsson pj. PLoS One. 2011 Jan 27;6(1):e16378. doi: 10.1371/journal.pone.0016378. PLoS One. 2011. PMID: 21298002 Free PMC article.

2

Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target.

Jakobsson PJ, Thorén S, Morgenstern R, Samuelsson B. Jakobsson PJ, et al. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7220-5. doi: 10.1073/pnas.96.13.7220. Proc Natl Acad Sci U S A. 1999. PMID: 10377395 Free PMC article.

3

Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4.

Thorén S, Jakobsson PJ. Thorén S, et al. Among authors: jakobsson pj. Eur J Biochem. 2000 Nov;267(21):6428-34. doi: 10.1046/j.1432-1327.2000.01735.x. Eur J Biochem. 2000. PMID: 11029586 Free article.

4

Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells.

Stichtenoth DO, Thorén S, Bian H, Peters-Golden M, Jakobsson PJ, Crofford LJ. Stichtenoth DO, et al. Among authors: jakobsson pj. J Immunol. 2001 Jul 1;167(1):469-74. doi: 10.4049/jimmunol.167.1.469. J Immunol. 2001. PMID: 11418684

5

Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis.

Engblom D, Saha S, Engström L, Westman M, Audoly LP, Jakobsson PJ, Blomqvist A. Engblom D, et al. Among authors: jakobsson pj. Nat Neurosci. 2003 Nov;6(11):1137-8. doi: 10.1038/nn1137. Epub 2003 Oct 19. Nat Neurosci. 2003. PMID: 14566340 Free article.

6

Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway.

Korotkova M, Westman M, Gheorghe KR, af Klint E, Trollmo C, Ulfgren AK, Klareskog L, Jakobsson PJ. Korotkova M, et al. Among authors: jakobsson pj. Arthritis Rheum. 2005 Nov;52(11):3439-47. doi: 10.1002/art.21390. Arthritis Rheum. 2005. PMID: 16255020 Free article. Clinical Trial.

7

The induced prostaglandin E2 pathway is a key regulator of the respiratory response to infection and hypoxia in neonates.

Hofstetter AO, Saha S, Siljehav V, Jakobsson PJ, Herlenius E. Hofstetter AO, et al. Among authors: jakobsson pj. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9894-9. doi: 10.1073/pnas.0611468104. Epub 2007 May 29. Proc Natl Acad Sci U S A. 2007. PMID: 17535900 Free PMC article.

8

Membrane prostaglandin E synthase-1: a novel therapeutic target.

Samuelsson B, Morgenstern R, Jakobsson PJ. Samuelsson B, et al. Among authors: jakobsson pj. Pharmacol Rev. 2007 Sep;59(3):207-24. doi: 10.1124/pr.59.3.1. Pharmacol Rev. 2007. PMID: 17878511 Review.

9

Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction.

Degousee N, Fazel S, Angoulvant D, Stefanski E, Pawelzik SC, Korotkova M, Arab S, Liu P, Lindsay TF, Zhuo S, Butany J, Li RK, Audoly L, Schmidt R, Angioni C, Geisslinger G, Jakobsson PJ, Rubin BB. Degousee N, et al. Among authors: jakobsson pj. Circulation. 2008 Apr 1;117(13):1701-10. doi: 10.1161/CIRCULATIONAHA.107.749739. Epub 2008 Mar 17. Circulation. 2008. PMID: 18347209

10

Structural basis for induced formation of the inflammatory mediator prostaglandin E2.

Jegerschöld C, Pawelzik SC, Purhonen P, Bhakat P, Gheorghe KR, Gyobu N, Mitsuoka K, Morgenstern R, Jakobsson PJ, Hebert H. Jegerschöld C, et al. Among authors: jakobsson pj. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11110-5. doi: 10.1073/pnas.0802894105. Epub 2008 Aug 5. Proc Natl Acad Sci U S A. 2008. PMID: 18682561 Free PMC article.

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