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Chromosomal instability confers intrinsic multidrug resistance.
Lee AJ, Endesfelder D, Rowan AJ, Walther A, Birkbak NJ, Futreal PA, Downward J, Szallasi Z, Tomlinson IP, Howell M, Kschischo M, Swanton C. Lee AJ, et al. Among authors: endesfelder d. Cancer Res. 2011 Mar 1;71(5):1858-70. doi: 10.1158/0008-5472.CAN-10-3604. Cancer Res. 2011. PMID: 21363922 Free PMC article.
Chromosomal instability determines taxane response.
Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li Q, Hardcastle T, Lee A, Roy R, East P, Kschischo M, Endesfelder D, Wylie P, Kim SN, Chen JG, Howell M, Ried T, Habermann JK, Auer G, Brenton JD, Szallasi Z, Downward J. Swanton C, et al. Among authors: endesfelder d. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8671-6. doi: 10.1073/pnas.0811835106. Epub 2009 May 19. Proc Natl Acad Sci U S A. 2009. PMID: 19458043 Free PMC article.
Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer.
Roylance R, Endesfelder D, Gorman P, Burrell RA, Sander J, Tomlinson I, Hanby AM, Speirs V, Richardson AL, Birkbak NJ, Eklund AC, Downward J, Kschischo M, Szallasi Z, Swanton C. Roylance R, et al. Among authors: endesfelder d. Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2183-94. doi: 10.1158/1055-9965.EPI-11-0343. Epub 2011 Jul 22. Cancer Epidemiol Biomarkers Prev. 2011. PMID: 21784954 Free PMC article.
CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction.
Lee AJ, Roylance R, Sander J, Gorman P, Endesfelder D, Kschischo M, Jones NP, East P, Nicke B, Spassieva S, Obeid LM, Birkbak NJ, Szallasi Z, McKnight NC, Rowan AJ, Speirs V, Hanby AM, Downward J, Tooze SA, Swanton C. Lee AJ, et al. Among authors: endesfelder d. J Pathol. 2012 Feb;226(3):482-94. doi: 10.1002/path.2998. Epub 2011 Oct 19. J Pathol. 2012. PMID: 21953249
Replication stress links structural and numerical cancer chromosomal instability.
Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N, Domingo E, Kanu N, Dewhurst SM, Gronroos E, Chew SK, Rowan AJ, Schenk A, Sheffer M, Howell M, Kschischo M, Behrens A, Helleday T, Bartek J, Tomlinson IP, Swanton C. Burrell RA, et al. Among authors: endesfelder d. Nature. 2013 Feb 28;494(7438):492-496. doi: 10.1038/nature11935. Nature. 2013. PMID: 23446422 Free PMC article.
Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.
Dewhurst SM, McGranahan N, Burrell RA, Rowan AJ, Grönroos E, Endesfelder D, Joshi T, Mouradov D, Gibbs P, Ward RL, Hawkins NJ, Szallasi Z, Sieber OM, Swanton C. Dewhurst SM, et al. Among authors: endesfelder d. Cancer Discov. 2014 Feb;4(2):175-185. doi: 10.1158/2159-8290.CD-13-0285. Epub 2014 Jan 19. Cancer Discov. 2014. PMID: 24436049 Free PMC article.
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