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Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).
Ghoreschi K, Jesson MI, Li X, Lee JL, Ghosh S, Alsup JW, Warner JD, Tanaka M, Steward-Tharp SM, Gadina M, Thomas CJ, Minnerly JC, Storer CE, LaBranche TP, Radi ZA, Dowty ME, Head RD, Meyer DM, Kishore N, O'Shea JJ. Ghoreschi K, et al. Among authors: steward tharp sm. J Immunol. 2011 Apr 1;186(7):4234-43. doi: 10.4049/jimmunol.1003668. Epub 2011 Mar 7. J Immunol. 2011. PMID: 21383241 Free PMC article.
Signal transduction and Th17 cell differentiation.
O'Shea JJ, Steward-Tharp SM, Laurence A, Watford WT, Wei L, Adamson AS, Fan S. O'Shea JJ, et al. Among authors: steward tharp sm. Microbes Infect. 2009 Apr;11(5):599-611. doi: 10.1016/j.micinf.2009.04.007. Epub 2009 Apr 18. Microbes Infect. 2009. PMID: 19379825 Free PMC article. Review.
A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.
Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun HW, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ. Steward-Tharp SM, et al. Blood. 2014 May 8;123(19):2978-87. doi: 10.1182/blood-2013-09-523167. Epub 2014 Mar 14. Blood. 2014. PMID: 24632714 Free PMC article.
IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation.
Renavikar PS, Sinha S, Brate AA, Borcherding N, Crawford MP, Steward-Tharp SM, Karandikar NJ. Renavikar PS, et al. Among authors: steward tharp sm. Front Immunol. 2020 Oct 28;11:568630. doi: 10.3389/fimmu.2020.568630. eCollection 2020. Front Immunol. 2020. PMID: 33193343 Free PMC article.
Altered expression of SIRPγ on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells.
Sinha S, Renavikar PS, Crawford MP, Steward-Tharp SM, Brate A, Tsalikian E, Tansey M, Shivapour ET, Cho T, Kamholz J, Karandikar NJ. Sinha S, et al. Among authors: steward tharp sm. PLoS One. 2020 Aug 27;15(8):e0238070. doi: 10.1371/journal.pone.0238070. eCollection 2020. PLoS One. 2020. PMID: 32853219 Free PMC article.