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Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity.
Xue CB, Chen L, Cao G, Zhang K, Wang A, Meloni D, Glenn J, Anand R, Xia M, Kong L, Huang T, Feng H, Zheng C, Li M, Galya L, Zhou J, Shin N, Baribaud F, Solomon K, Scherle P, Zhao B, Diamond S, Emm T, Keller D, Contel N, Yeleswaram S, Vaddi K, Hollis G, Newton R, Friedman S, Metcalf B. Xue CB, et al. ACS Med Chem Lett. 2010 Aug 25;1(9):483-7. doi: 10.1021/ml1001536. eCollection 2010 Dec 9. ACS Med Chem Lett. 2010. PMID: 24900235 Free PMC article.
Identification and characterization of INCB9471, an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5 with potent inhibitory activity against monocyte migration and HIV-1 infection.
Shin N, Solomon K, Zhou N, Wang KH, Garlapati V, Thomas B, Li Y, Covington M, Baribaud F, Erickson-Viitanen S, Czerniak P, Contel N, Liu P, Burn T, Hollis G, Yeleswaram S, Vaddi K, Xue CB, Metcalf B, Friedman S, Scherle P, Newton R. Shin N, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):228-39. doi: 10.1124/jpet.111.179531. Epub 2011 Apr 1. J Pharmacol Exp Ther. 2011. PMID: 21459966
Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344.
Brodmerkel CM, Huber R, Covington M, Diamond S, Hall L, Collins R, Leffet L, Gallagher K, Feldman P, Collier P, Stow M, Gu X, Baribaud F, Shin N, Thomas B, Burn T, Hollis G, Yeleswaram S, Solomon K, Friedman S, Wang A, Xue CB, Newton RC, Scherle P, Vaddi K. Brodmerkel CM, et al. J Immunol. 2005 Oct 15;175(8):5370-8. doi: 10.4049/jimmunol.175.8.5370. J Immunol. 2005. PMID: 16210643
Detailed molecular structure (XRD), conformational search, spectroscopic characterization (IR, Raman, UV, fluorescence), quantum mechanical properties and bioactivity prediction of a pyrrole analogue.
Srikanth KE, Veeraiah A, Pooventhiran T, Thomas R, Solomon KA, Soma Raju CJ, Latha JNL. Srikanth KE, et al. Among authors: solomon ka. Heliyon. 2020 Jun 3;6(6):e04106. doi: 10.1016/j.heliyon.2020.e04106. eCollection 2020 Jun. Heliyon. 2020. PMID: 32529077 Free PMC article.
Case 237: Renal Cell Carcinoma with Osseous Metaplasia.
Lai BM, Ka SY, Kan WK, Lam MW, Lee TF, Lui YH, Khoo JL. Lai BM, et al. Among authors: ka sy. Radiology. 2017 Jan;282(1):293-298. doi: 10.1148/radiol.2016140817. Radiology. 2017. PMID: 28005510
Case 237.
Lai BM, Ka SY, Kan WK, Lam MW, Lee TF, Lui YH, Khoo JL. Lai BM, et al. Among authors: ka sy. Radiology. 2016 Sep;280(3):969-71. doi: 10.1148/radiol.2016140816. Radiology. 2016. PMID: 27533291 No abstract available.
38 results