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Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach.
Nguyen MH, Ye HF, Xu Y, Truong L, Horsey A, Zhao P, Styduhar ED, Frascella M, Leffet L, Federowicz K, Behshad E, Wang A, Zhang K, Witten MR, Qi C, Jalluri R, Lai CT, Atasoylu O, Harris JJ, Hess R, Lin L, Zhang G, Covington M, Diamond S, Yao W, Vechorkin O. Nguyen MH, et al. Among authors: harris jj. ACS Med Chem Lett. 2023 Feb 28;14(3):312-318. doi: 10.1021/acsmedchemlett.3c00003. eCollection 2023 Mar 9. ACS Med Chem Lett. 2023. PMID: 36923909 Free PMC article.
Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.
Shvartsbart A, Roach JJ, Witten MR, Koblish H, Harris JJ, Covington M, Hess R, Lin L, Frascella M, Truong L, Leffet L, Conlen P, Beshad E, Klabe R, Katiyar K, Kaldon L, Young-Sciame R, He X, Petusky S, Chen KJ, Horsey A, Lei HT, Epling LB, Deller MC, Vechorkin O, Yao W. Shvartsbart A, et al. Among authors: harris jj. J Med Chem. 2022 Nov 24;65(22):15433-15442. doi: 10.1021/acs.jmedchem.2c01366. Epub 2022 Nov 10. J Med Chem. 2022. PMID: 36356320
Optimising the energetic cost of the glutamatergic synapse.
Lezmy J, Harris JJ, Attwell D. Lezmy J, et al. Among authors: harris jj. Neuropharmacology. 2021 Oct 1;197:108727. doi: 10.1016/j.neuropharm.2021.108727. Epub 2021 Jul 24. Neuropharmacology. 2021. PMID: 34314736 Review.
Fast odour dynamics are encoded in the olfactory system and guide behaviour.
Ackels T, Erskine A, Dasgupta D, Marin AC, Warner TPA, Tootoonian S, Fukunaga I, Harris JJ, Schaefer AT. Ackels T, et al. Among authors: harris jj. Nature. 2021 May;593(7860):558-563. doi: 10.1038/s41586-021-03514-2. Epub 2021 May 5. Nature. 2021. PMID: 33953395 Free PMC article.
A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity.
Rios-Doria J, Favata M, Lasky K, Feldman P, Lo Y, Yang G, Stevens C, Wen X, Sehra S, Katiyar K, Liu K, Wynn R, Harris JJ, Ye M, Spitz S, Wang X, He C, Li YL, Yao W, Covington M, Scherle P, Koblish H. Rios-Doria J, et al. Among authors: harris jj. Front Oncol. 2020 Dec 7;10:598477. doi: 10.3389/fonc.2020.598477. eCollection 2020. Front Oncol. 2020. PMID: 33425754 Free PMC article.
Effects of Braiding Parameters on Tissue Engineered Vascular Graft Development.
Zbinden JC, Blum KM, Berman AG, Ramachandra AB, Szafron JM, Kerr KE, Anderson JL, Sangha GS, Earl CC, Nigh NR, Mirhaidari GJM, Reinhardt JW, Chang YC, Yi T, Smalley R, Gabriele PD, Harris JJ, Humphrey JD, Goergen CJ, Breuer CK. Zbinden JC, et al. Among authors: harris jj. Adv Healthc Mater. 2020 Dec;9(24):e2001093. doi: 10.1002/adhm.202001093. Epub 2020 Oct 15. Adv Healthc Mater. 2020. PMID: 33063452
164 results