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HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.
Phillips A, Teunisse A, Lam S, Lodder K, Darley M, Emaduddin M, Wolf A, Richter J, de Lange J, Verlaan-de Vries M, Lenos K, Böhnke A, Bartel F, Blaydes JP, Jochemsen AG. Phillips A, et al. Among authors: de lange j. J Biol Chem. 2010 Sep 17;285(38):29111-27. doi: 10.1074/jbc.M110.129726. Epub 2010 Jul 20. J Biol Chem. 2010. PMID: 20659896 Free PMC article.
Chk2 mediates RITA-induced apoptosis.
de Lange J, Verlaan-de Vries M, Teunisse AF, Jochemsen AG. de Lange J, et al. Cell Death Differ. 2012 Jun;19(6):980-9. doi: 10.1038/cdd.2011.182. Epub 2011 Dec 9. Cell Death Differ. 2012. PMID: 22158418 Free PMC article.
MDM4 is a key therapeutic target in cutaneous melanoma.
Gembarska A, Luciani F, Fedele C, Russell EA, Dewaele M, Villar S, Zwolinska A, Haupt S, de Lange J, Yip D, Goydos J, Haigh JJ, Haupt Y, Larue L, Jochemsen A, Shi H, Moriceau G, Lo RS, Ghanem G, Shackleton M, Bernal F, Marine JC. Gembarska A, et al. Among authors: de lange j. Nat Med. 2012 Aug;18(8):1239-47. doi: 10.1038/nm.2863. Epub 2012 Jul 22. Nat Med. 2012. PMID: 22820643 Free PMC article.
Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.
de Lange J, Faramarz A, Oostra AB, de Menezes RX, van der Meulen IH, Rooimans MA, Rockx DA, Brakenhoff RH, van Beusechem VW, King RW, de Winter JP, Wolthuis RMF. de Lange J, et al. Among authors: de menezes rx, de winter jp. Nat Commun. 2015 Oct 1;6:8399. doi: 10.1038/ncomms9399. Nat Commun. 2015. PMID: 26423134 Free PMC article.
Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells.
Schuurhuis GJ, van Heijningen TH, Cervantes A, Pinedo HM, de Lange JH, Keizer HG, Broxterman HJ, Baak JP, Lankelma J. Schuurhuis GJ, et al. Among authors: de lange jh. Br J Cancer. 1993 Nov;68(5):898-908. doi: 10.1038/bjc.1993.452. Br J Cancer. 1993. PMID: 8105865 Free PMC article.
504 results