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A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis.
Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M, Geboes L, Louagie E, Mc Guire C, Vereecke L, Chu Y, Boon L, Staelens S, Matthys P, Lambrecht BN, Schmidt-Supprian M, Pasparakis M, Elewaut D, Beyaert R, van Loo G. Matmati M, et al. Among authors: maelfait j. Nat Genet. 2011 Aug 14;43(9):908-12. doi: 10.1038/ng.874. Nat Genet. 2011. PMID: 21841782
Non-apoptotic functions of caspase-8.
Maelfait J, Beyaert R. Maelfait J, et al. Biochem Pharmacol. 2008 Dec 1;76(11):1365-73. doi: 10.1016/j.bcp.2008.07.034. Epub 2008 Aug 6. Biochem Pharmacol. 2008. PMID: 18761323 Review.
A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.
Maelfait J, Roose K, Vereecke L, Mc Guire C, Sze M, Schuijs MJ, Willart M, Ibañez LI, Hammad H, Lambrecht BN, Beyaert R, Saelens X, van Loo G. Maelfait J, et al. PLoS Pathog. 2016 Jan 27;12(1):e1005410. doi: 10.1371/journal.ppat.1005410. eCollection 2016 Jan. PLoS Pathog. 2016. PMID: 26815999 Free PMC article.
OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.
Verboom L, Martens A, Priem D, Hoste E, Sze M, Vikkula H, Van Hove L, Voet S, Roels J, Maelfait J, Bongiovanni L, de Bruin A, Scott CL, Saeys Y, Pasparakis M, Bertrand MJM, van Loo G. Verboom L, et al. Among authors: maelfait j. Cell Rep. 2020 Feb 18;30(7):2237-2247.e6. doi: 10.1016/j.celrep.2020.01.028. Cell Rep. 2020. PMID: 32075762 Free article.
ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.
de Reuver R, Verdonck S, Dierick E, Nemegeer J, Hessmann E, Ahmad S, Jans M, Blancke G, Van Nieuwerburgh F, Botzki A, Vereecke L, van Loo G, Declercq W, Hur S, Vandenabeele P, Maelfait J. de Reuver R, et al. Among authors: maelfait j. Nature. 2022 Jul;607(7920):784-789. doi: 10.1038/s41586-022-04974-w. Epub 2022 Jul 20. Nature. 2022. PMID: 35859175
51 results