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ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria.
Houben D, Demangel C, van Ingen J, Perez J, Baldeón L, Abdallah AM, Caleechurn L, Bottai D, van Zon M, de Punder K, van der Laan T, Kant A, Bossers-de Vries R, Willemsen P, Bitter W, van Soolingen D, Brosch R, van der Wel N, Peters PJ. Houben D, et al. Among authors: abdallah am. Cell Microbiol. 2012 Aug;14(8):1287-98. doi: 10.1111/j.1462-5822.2012.01799.x. Epub 2012 May 8. Cell Microbiol. 2012. PMID: 22524898
Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) protein domains target LipY lipases of pathogenic mycobacteria to the cell surface via the ESX-5 pathway.
Daleke MH, Cascioferro A, de Punder K, Ummels R, Abdallah AM, van der Wel N, Peters PJ, Luirink J, Manganelli R, Bitter W. Daleke MH, et al. Among authors: abdallah am. J Biol Chem. 2011 May 27;286(21):19024-34. doi: 10.1074/jbc.M110.204966. Epub 2011 Apr 6. J Biol Chem. 2011. PMID: 21471225 Free PMC article.
ESX-5-deficient Mycobacterium marinum is hypervirulent in adult zebrafish.
Weerdenburg EM, Abdallah AM, Mitra S, de Punder K, van der Wel NN, Bird S, Appelmelk BJ, Bitter W, van der Sar AM. Weerdenburg EM, et al. Among authors: abdallah am. Cell Microbiol. 2012 May;14(5):728-39. doi: 10.1111/j.1462-5822.2012.01755.x. Epub 2012 Feb 15. Cell Microbiol. 2012. PMID: 22256857
Type VII secretion--mycobacteria show the way.
Abdallah AM, Gey van Pittius NC, Champion PA, Cox J, Luirink J, Vandenbroucke-Grauls CM, Appelmelk BJ, Bitter W. Abdallah AM, et al. Nat Rev Microbiol. 2007 Nov;5(11):883-91. doi: 10.1038/nrmicro1773. Nat Rev Microbiol. 2007. PMID: 17922044
Genome-wide transposon mutagenesis indicates that Mycobacterium marinum customizes its virulence mechanisms for survival and replication in different hosts.
Weerdenburg EM, Abdallah AM, Rangkuti F, Abd El Ghany M, Otto TD, Adroub SA, Molenaar D, Ummels R, Ter Veen K, van Stempvoort G, van der Sar AM, Ali S, Langridge GC, Thomson NR, Pain A, Bitter W. Weerdenburg EM, et al. Among authors: abdallah am. Infect Immun. 2015 May;83(5):1778-88. doi: 10.1128/IAI.03050-14. Epub 2015 Feb 17. Infect Immun. 2015. PMID: 25690095 Free PMC article.
173 results