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Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age.
Desta Z, Kreutz Y, Nguyen AT, Li L, Skaar T, Kamdem LK, Henry NL, Hayes DF, Storniolo AM, Stearns V, Hoffmann E, Tyndale RF, Flockhart DA. Desta Z, et al. Among authors: li l. Clin Pharmacol Ther. 2011 Nov;90(5):693-700. doi: 10.1038/clpt.2011.174. Epub 2011 Oct 5. Clin Pharmacol Ther. 2011. PMID: 21975350 Free PMC article. Clinical Trial.
Comparison of changes in the lipid profile of postmenopausal women with early stage breast cancer treated with exemestane or letrozole.
Bell LN, Nguyen AT, Li L, Desta Z, Henry NL, Hayes DF, Wolff AC, Stearns V, Storniolo AM, Flockhart DA; Consortium on Breast Cancer Pharmacogenomics (COBRA). Bell LN, et al. Among authors: li l. J Clin Pharmacol. 2012 Dec;52(12):1852-60. doi: 10.1177/0091270011424153. Epub 2011 Dec 15. J Clin Pharmacol. 2012. PMID: 22174434 Free PMC article. Clinical Trial.
Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover.
Oesterreich S, Henry NL, Kidwell KM, Van Poznak CH, Skaar TC, Dantzer J, Li L, Hangartner TN, Peacock M, Nguyen AT, Rae JM, Desta Z, Philips S, Storniolo AM, Stearns V, Hayes DF, Flockhart DA. Oesterreich S, et al. Among authors: li l. Breast Cancer Res Treat. 2015 Nov;154(2):263-73. doi: 10.1007/s10549-015-3608-8. Epub 2015 Nov 4. Breast Cancer Res Treat. 2015. PMID: 26536870 Free PMC article.
Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer.
Robarge JD, Desta Z, Nguyen AT, Li L, Hertz D, Rae JM, Hayes DF, Storniolo AM, Stearns V, Flockhart DA, Skaar TC, Henry NL. Robarge JD, et al. Among authors: li l. Breast Cancer Res Treat. 2017 Feb;161(3):453-461. doi: 10.1007/s10549-016-4077-4. Epub 2016 Dec 9. Breast Cancer Res Treat. 2017. PMID: 27943008 Free PMC article. Clinical Trial.
Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen.
Ntukidem NI, Nguyen AT, Stearns V, Rehman M, Schott A, Skaar T, Jin Y, Blanche P, Li L, Lemler S, Hayden J, Krauss RM, Desta Z, Flockhart DA, Hayes DF; Consortium on Breast Cancer Pharmacogenomics. Ntukidem NI, et al. Among authors: li l. Clin Pharmacol Ther. 2008 May;83(5):702-10. doi: 10.1038/sj.clpt.6100343. Epub 2007 Aug 22. Clin Pharmacol Ther. 2008. PMID: 17713466 Free PMC article. Clinical Trial.
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