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Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent.
Aminkeng F, Ross CJ, Rassekh SR, Brunham LR, Sistonen J, Dube MP, Ibrahim M, Nyambo TB, Omar SA, Froment A, Bodo JM, Tishkoff S, Carleton BC, Hayden MR; Canadian Pharmacogenomics Network for Drug Safety Consortium. Aminkeng F, et al. Among authors: omar sa. Pharmacogenomics J. 2014 Apr;14(2):160-70. doi: 10.1038/tpj.2013.13. Epub 2013 Apr 16. Pharmacogenomics J. 2014. PMID: 23588107 Free PMC article.
Haplotype variation and genotype imputation in African populations.
Huang L, Jakobsson M, Pemberton TJ, Ibrahim M, Nyambo T, Omar S, Pritchard JK, Tishkoff SA, Rosenberg NA. Huang L, et al. Among authors: omar s. Genet Epidemiol. 2011 Dec;35(8):766-80. doi: 10.1002/gepi.20626. Genet Epidemiol. 2011. PMID: 22125220 Free PMC article.
Convergent adaptation of human lactase persistence in Africa and Europe.
Tishkoff SA, Reed FA, Ranciaro A, Voight BF, Babbitt CC, Silverman JS, Powell K, Mortensen HM, Hirbo JB, Osman M, Ibrahim M, Omar SA, Lema G, Nyambo TB, Ghori J, Bumpstead S, Pritchard JK, Wray GA, Deloukas P. Tishkoff SA, et al. Among authors: omar sa. Nat Genet. 2007 Jan;39(1):31-40. doi: 10.1038/ng1946. Epub 2006 Dec 10. Nat Genet. 2007. PMID: 17159977 Free PMC article.
The genetic structure and history of Africans and African Americans.
Tishkoff SA, Reed FA, Friedlaender FR, Ehret C, Ranciaro A, Froment A, Hirbo JB, Awomoyi AA, Bodo JM, Doumbo O, Ibrahim M, Juma AT, Kotze MJ, Lema G, Moore JH, Mortensen H, Nyambo TB, Omar SA, Powell K, Pretorius GS, Smith MW, Thera MA, Wambebe C, Weber JL, Williams SM. Tishkoff SA, et al. Among authors: omar sa. Science. 2009 May 22;324(5930):1035-44. doi: 10.1126/science.1172257. Epub 2009 Apr 30. Science. 2009. PMID: 19407144 Free PMC article.
Effects of natural selection and gene conversion on the evolution of human glycophorins coding for MNS blood polymorphisms in malaria-endemic African populations.
Ko WY, Kaercher KA, Giombini E, Marcatili P, Froment A, Ibrahim M, Lema G, Nyambo TB, Omar SA, Wambebe C, Ranciaro A, Hirbo JB, Tishkoff SA. Ko WY, et al. Among authors: omar sa. Am J Hum Genet. 2011 Jun 10;88(6):741-754. doi: 10.1016/j.ajhg.2011.05.005. Am J Hum Genet. 2011. PMID: 21664997 Free PMC article.
Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa.
Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA. Campbell MC, et al. Among authors: omar sa. J Hum Genet. 2014 Jun;59(6):349-52. doi: 10.1038/jhg.2014.29. Epub 2014 May 1. J Hum Genet. 2014. PMID: 24785689 Free PMC article.
Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection.
Zhang C, Verma A, Feng Y, Melo MCR, McQuillan M, Hansen M, Lucas A, Park J, Ranciaro A, Thompson S, Rubel MA, Campbell MC, Beggs W, Hirbo J, Wata Mpoloka S, George Mokone G; Regeneron Genetic Center; Nyambo T, Wolde Meskel D, Belay G, Fokunang C, Njamnshi AK, Omar SA, Williams SM, Rader DJ, Ritchie MD, de la Fuente-Nunez C, Sirugo G, Tishkoff SA. Zhang C, et al. Among authors: omar sa. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2123000119. doi: 10.1073/pnas.2123000119. Epub 2022 May 17. Proc Natl Acad Sci U S A. 2022. PMID: 35580180 Free PMC article.
163 results