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The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.
Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P. Nassini R, et al. Among authors: dussor g. Brain. 2012 Feb;135(Pt 2):376-90. doi: 10.1093/brain/awr272. Epub 2011 Oct 27. Brain. 2012. PMID: 22036959
Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers.
De Felice M, Ossipov MH, Wang R, Dussor G, Lai J, Meng ID, Chichorro J, Andrews JS, Rakhit S, Maddaford S, Dodick D, Porreca F. De Felice M, et al. Among authors: dussor g. Brain. 2010 Aug;133(Pt 8):2475-88. doi: 10.1093/brain/awq159. Epub 2010 Jul 13. Brain. 2010. PMID: 20627971 Free PMC article.
Central modulation of pain.
Ossipov MH, Dussor GO, Porreca F. Ossipov MH, et al. J Clin Invest. 2010 Nov;120(11):3779-87. doi: 10.1172/JCI43766. Epub 2010 Nov 1. J Clin Invest. 2010. PMID: 21041960 Free PMC article. Review.
Activation of TRPA1 on dural afferents: a potential mechanism of headache pain.
Edelmayer RM, Le LN, Yan J, Wei X, Nassini R, Materazzi S, Preti D, Appendino G, Geppetti P, Dodick DW, Vanderah TW, Porreca F, Dussor G. Edelmayer RM, et al. Among authors: dussor g. Pain. 2012 Sep;153(9):1949-1958. doi: 10.1016/j.pain.2012.06.012. Epub 2012 Jul 17. Pain. 2012. PMID: 22809691 Free PMC article.
Capturing the aversive state of cephalic pain preclinically.
De Felice M, Eyde N, Dodick D, Dussor GO, Ossipov MH, Fields HL, Porreca F. De Felice M, et al. Ann Neurol. 2013 Aug;74(2):257-65. doi: 10.1002/ana.23922. Epub 2013 Sep 10. Ann Neurol. 2013. PMID: 23686557 Free PMC article.
Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel.
Materazzi S, Benemei S, Fusi C, Gualdani R, De Siena G, Vastani N, Andersson DA, Trevisan G, Moncelli MR, Wei X, Dussor G, Pollastro F, Patacchini R, Appendino G, Geppetti P, Nassini R. Materazzi S, et al. Among authors: dussor g. Pain. 2013 Dec;154(12):2750-2758. doi: 10.1016/j.pain.2013.08.002. Epub 2013 Aug 8. Pain. 2013. PMID: 23933184 Free PMC article.
Targeting TRP channels for novel migraine therapeutics.
Dussor G, Yan J, Xie JY, Ossipov MH, Dodick DW, Porreca F. Dussor G, et al. ACS Chem Neurosci. 2014 Nov 19;5(11):1085-96. doi: 10.1021/cn500083e. Epub 2014 Aug 29. ACS Chem Neurosci. 2014. PMID: 25138211 Free PMC article. Review.
128 results