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The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.
Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P. Nassini R, et al. Among authors: materazzi s. Brain. 2012 Feb;135(Pt 2):376-90. doi: 10.1093/brain/awr272. Epub 2011 Oct 27. Brain. 2012. PMID: 22036959
Cough: The Emerging Role of the TRPA1 Channel.
Geppetti P, Patacchini R, Nassini R, Materazzi S. Geppetti P, et al. Among authors: materazzi s. Lung. 2010 Jan;188 Suppl 1:S63-8. doi: 10.1007/s00408-009-9201-3. Epub 2009 Nov 30. Lung. 2010. PMID: 20091046 Review.
Activation of TRPA1 on dural afferents: a potential mechanism of headache pain.
Edelmayer RM, Le LN, Yan J, Wei X, Nassini R, Materazzi S, Preti D, Appendino G, Geppetti P, Dodick DW, Vanderah TW, Porreca F, Dussor G. Edelmayer RM, et al. Among authors: materazzi s. Pain. 2012 Sep;153(9):1949-1958. doi: 10.1016/j.pain.2012.06.012. Epub 2012 Jul 17. Pain. 2012. PMID: 22809691 Free PMC article.
Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel.
Materazzi S, Benemei S, Fusi C, Gualdani R, De Siena G, Vastani N, Andersson DA, Trevisan G, Moncelli MR, Wei X, Dussor G, Pollastro F, Patacchini R, Appendino G, Geppetti P, Nassini R. Materazzi S, et al. Pain. 2013 Dec;154(12):2750-2758. doi: 10.1016/j.pain.2013.08.002. Epub 2013 Aug 8. Pain. 2013. PMID: 23933184 Free PMC article.
128 results