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The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.
Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P. Nassini R, et al. Among authors: nilius b. Brain. 2012 Feb;135(Pt 2):376-90. doi: 10.1093/brain/awr272. Epub 2011 Oct 27. Brain. 2012. PMID: 22036959
Umbellulone modulates TRP channels.
Zhong J, Minassi A, Prenen J, Taglialatela-Scafati O, Appendino G, Nilius B. Zhong J, et al. Among authors: nilius b. Pflugers Arch. 2011 Dec;462(6):861-70. doi: 10.1007/s00424-011-1043-1. Epub 2011 Oct 29. Pflugers Arch. 2011. PMID: 22038323
Irritating channels: the case of TRPA1.
Nilius B, Prenen J, Owsianik G. Nilius B, et al. J Physiol. 2011 Apr 1;589(Pt 7):1543-9. doi: 10.1113/jphysiol.2010.200717. Epub 2010 Nov 15. J Physiol. 2011. PMID: 21078588 Free PMC article. Review.
Ligustilide: a novel TRPA1 modulator.
Zhong J, Pollastro F, Prenen J, Zhu Z, Appendino G, Nilius B. Zhong J, et al. Among authors: nilius b. Pflugers Arch. 2011 Dec;462(6):841-9. doi: 10.1007/s00424-011-1021-7. Epub 2011 Sep 6. Pflugers Arch. 2011. PMID: 21894528
499 results