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The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.
Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P. Nassini R, et al. Among authors: preti d. Brain. 2012 Feb;135(Pt 2):376-90. doi: 10.1093/brain/awr272. Epub 2011 Oct 27. Brain. 2012. PMID: 22036959
Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents.
Nassini R, Materazzi S, Andrè E, Sartiani L, Aldini G, Trevisani M, Carnini C, Massi D, Pedretti P, Carini M, Cerbai E, Preti D, Villetti G, Civelli M, Trevisan G, Azzari C, Stokesberry S, Sadofsky L, McGarvey L, Patacchini R, Geppetti P. Nassini R, et al. Among authors: preti d. FASEB J. 2010 Dec;24(12):4904-16. doi: 10.1096/fj.10-162438. Epub 2010 Aug 18. FASEB J. 2010. PMID: 20720158
7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: a promising approach for treating pain and inflammation.
Baraldi PG, Romagnoli R, Saponaro G, Aghazadeh Tabrizi M, Baraldi S, Pedretti P, Fusi C, Nassini R, Materazzi S, Geppetti P, Preti D. Baraldi PG, et al. Among authors: preti d. Bioorg Med Chem. 2012 Mar 1;20(5):1690-8. doi: 10.1016/j.bmc.2012.01.020. Epub 2012 Jan 24. Bioorg Med Chem. 2012. PMID: 22325155
Activation of TRPA1 on dural afferents: a potential mechanism of headache pain.
Edelmayer RM, Le LN, Yan J, Wei X, Nassini R, Materazzi S, Preti D, Appendino G, Geppetti P, Dodick DW, Vanderah TW, Porreca F, Dussor G. Edelmayer RM, et al. Among authors: preti d. Pain. 2012 Sep;153(9):1949-1958. doi: 10.1016/j.pain.2012.06.012. Epub 2012 Jul 17. Pain. 2012. PMID: 22809691 Free PMC article.
The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives.
Nassini R, Fusi C, Materazzi S, Coppi E, Tuccinardi T, Marone IM, De Logu F, Preti D, Tonello R, Chiarugi A, Patacchini R, Geppetti P, Benemei S. Nassini R, et al. Among authors: preti d. Br J Pharmacol. 2015 Jul;172(13):3397-411. doi: 10.1111/bph.13129. Epub 2015 Apr 24. Br J Pharmacol. 2015. PMID: 25765567 Free PMC article.
102 results