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The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.
Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P. Nassini R, et al. Among authors: sadofsky l. Brain. 2012 Feb;135(Pt 2):376-90. doi: 10.1093/brain/awr272. Epub 2011 Oct 27. Brain. 2012. PMID: 22036959
Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents.
Nassini R, Materazzi S, Andrè E, Sartiani L, Aldini G, Trevisani M, Carnini C, Massi D, Pedretti P, Carini M, Cerbai E, Preti D, Villetti G, Civelli M, Trevisan G, Azzari C, Stokesberry S, Sadofsky L, McGarvey L, Patacchini R, Geppetti P. Nassini R, et al. Among authors: sadofsky l. FASEB J. 2010 Dec;24(12):4904-16. doi: 10.1096/fj.10-162438. Epub 2010 Aug 18. FASEB J. 2010. PMID: 20720158
TRPA1 agonists evoke coughing in guinea pig and human volunteers.
Birrell MA, Belvisi MG, Grace M, Sadofsky L, Faruqi S, Hele DJ, Maher SA, Freund-Michel V, Morice AH. Birrell MA, et al. Among authors: sadofsky l. Am J Respir Crit Care Med. 2009 Dec 1;180(11):1042-7. doi: 10.1164/rccm.200905-0665OC. Epub 2009 Sep 3. Am J Respir Crit Care Med. 2009. PMID: 19729665 Free PMC article.
Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF).
Vancauwenberghe E, Noyer L, Derouiche S, Lemonnier L, Gosset P, Sadofsky LR, Mariot P, Warnier M, Bokhobza A, Slomianny C, Mauroy B, Bonnal JL, Dewailly E, Delcourt P, Allart L, Desruelles E, Prevarskaya N, Roudbaraki M. Vancauwenberghe E, et al. Among authors: sadofsky lr. Mol Carcinog. 2017 Aug;56(8):1851-1867. doi: 10.1002/mc.22642. Epub 2017 May 22. Mol Carcinog. 2017. PMID: 28277613 Free article.
36 results