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The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.
Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P. Nassini R, et al. Brain. 2012 Feb;135(Pt 2):376-90. doi: 10.1093/brain/awr272. Epub 2011 Oct 27. Brain. 2012. PMID: 22036959
Cannabinoids: occurrence and medicinal chemistry.
Appendino G, Chianese G, Taglialatela-Scafati O. Appendino G, et al. Curr Med Chem. 2011;18(7):1085-99. doi: 10.2174/092986711794940888. Curr Med Chem. 2011. PMID: 21254969 Review.
Umbellulone modulates TRP channels.
Zhong J, Minassi A, Prenen J, Taglialatela-Scafati O, Appendino G, Nilius B. Zhong J, et al. Pflugers Arch. 2011 Dec;462(6):861-70. doi: 10.1007/s00424-011-1043-1. Epub 2011 Oct 29. Pflugers Arch. 2011. PMID: 22038323
181 results