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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, Yamada SD, Peter ME, Gwin K, Lengyel E. Nieman KM, et al. Among authors: hotamisligil gs. Nat Med. 2011 Oct 30;17(11):1498-503. doi: 10.1038/nm.2492. Nat Med. 2011. PMID: 22037646 Free PMC article.
The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.
Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH. Lynes MD, et al. Among authors: hotamisligil gs. Nat Med. 2017 May;23(5):631-637. doi: 10.1038/nm.4297. Epub 2017 Mar 27. Nat Med. 2017. PMID: 28346411 Free PMC article.
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.
Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Furuhashi M, et al. Among authors: hotamisligil gs. Nature. 2007 Jun 21;447(7147):959-65. doi: 10.1038/nature05844. Epub 2007 Jun 6. Nature. 2007. PMID: 17554340 Free PMC article.
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.
Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS. Pan Y, et al. Among authors: hotamisligil gs. Nature. 2017 Mar 9;543(7644):252-256. doi: 10.1038/nature21379. Epub 2017 Feb 20. Nature. 2017. PMID: 28219080 Free PMC article.
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.
Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS. Bartelt A, et al. Among authors: hotamisligil gs. Nat Med. 2018 Mar;24(3):292-303. doi: 10.1038/nm.4481. Epub 2018 Feb 5. Nat Med. 2018. PMID: 29400713 Free PMC article.
A hormone complex of FABP4 and nucleoside kinases regulates islet function.
Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GS. Prentice KJ, et al. Among authors: hotamisligil gs. Nature. 2021 Dec;600(7890):720-726. doi: 10.1038/s41586-021-04137-3. Epub 2021 Dec 8. Nature. 2021. PMID: 34880500 Free PMC article.
205 results