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Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein.
Gorchakov R, Wang E, Leal G, Forrester NL, Plante K, Rossi SL, Partidos CD, Adams AP, Seymour RL, Weger J, Borland EM, Sherman MB, Powers AM, Osorio JE, Weaver SC. Gorchakov R, et al. Among authors: leal g. J Virol. 2012 Jun;86(11):6084-96. doi: 10.1128/JVI.06449-11. Epub 2012 Mar 28. J Virol. 2012. PMID: 22457519 Free PMC article.
A chikungunya fever vaccine utilizing an insect-specific virus platform.
Erasmus JH, Auguste AJ, Kaelber JT, Luo H, Rossi SL, Fenton K, Leal G, Kim DY, Chiu W, Wang T, Frolov I, Nasar F, Weaver SC. Erasmus JH, et al. Among authors: leal g. Nat Med. 2017 Feb;23(2):192-199. doi: 10.1038/nm.4253. Epub 2016 Dec 19. Nat Med. 2017. PMID: 27991917 Free PMC article.
Recombinant Isfahan Virus and Vesicular Stomatitis Virus Vaccine Vectors Provide Durable, Multivalent, Single-Dose Protection against Lethal Alphavirus Challenge.
Nasar F, Matassov D, Seymour RL, Latham T, Gorchakov RV, Nowak RM, Leal G, Hamm S, Eldridge JH, Tesh RB, Clarke DK, Weaver SC. Nasar F, et al. Among authors: leal g. J Virol. 2017 Mar 29;91(8):e01729-16. doi: 10.1128/JVI.01729-16. Print 2017 Apr 15. J Virol. 2017. PMID: 28148802 Free PMC article.
237 results