Flaherty KT - Search Results

1

Improved survival with MEK inhibition in BRAF-mutated melanoma.

Flaherty KT, Robert C, Hersey P, Nathan P, Garbe C, Milhem M, Demidov LV, Hassel JC, Rutkowski P, Mohr P, Dummer R, Trefzer U, Larkin JM, Utikal J, Dreno B, Nyakas M, Middleton MR, Becker JC, Casey M, Sherman LJ, Wu FS, Ouellet D, Martin AM, Patel K, Schadendorf D; METRIC Study Group. Flaherty KT, et al. N Engl J Med. 2012 Jul 12;367(2):107-14. doi: 10.1056/NEJMoa1203421. Epub 2012 Jun 4. N Engl J Med. 2012. PMID: 22663011 Free article. Clinical Trial.

2

A phase I and pharmacokinetic study of lapatinib in combination with infusional 5-fluorouracil, leucovorin and irinotecan.

Midgley RS, Kerr DJ, Flaherty KT, Stevenson JP, Pratap SE, Koch KM, Smith DA, Versola M, Fleming RA, Ward C, O'Dwyer PJ, Middleton MR. Midgley RS, et al. Among authors: flaherty kt. Ann Oncol. 2007 Dec;18(12):2025-9. doi: 10.1093/annonc/mdm366. Epub 2007 Sep 9. Ann Oncol. 2007. PMID: 17846021 Free article. Clinical Trial.

3

Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.

Lasithiotakis KG, Sinnberg TW, Schittek B, Flaherty KT, Kulms D, Maczey E, Garbe C, Meier FE. Lasithiotakis KG, et al. Among authors: flaherty kt. J Invest Dermatol. 2008 Aug;128(8):2013-23. doi: 10.1038/jid.2008.44. Epub 2008 Mar 6. J Invest Dermatol. 2008. PMID: 18323781 Free article.

4

Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.

Sinnberg T, Lasithiotakis K, Niessner H, Schittek B, Flaherty KT, Kulms D, Maczey E, Campos M, Gogel J, Garbe C, Meier F. Sinnberg T, et al. Among authors: flaherty kt. J Invest Dermatol. 2009 Jun;129(6):1500-15. doi: 10.1038/jid.2008.379. Epub 2008 Dec 11. J Invest Dermatol. 2009. PMID: 19078992 Free article.

5

Integrating BRAF/MEK inhibitors into combination therapy for melanoma.

Smalley KS, Flaherty KT. Smalley KS, et al. Among authors: flaherty kt. Br J Cancer. 2009 Feb 10;100(3):431-5. doi: 10.1038/sj.bjc.6604891. Epub 2009 Jan 20. Br J Cancer. 2009. PMID: 19156138 Free PMC article. Review.

6

Meeting report: consensus from the first and second Global Workshops in Melanoma November 19-20, 2008.

Agarwala SS, Becker JC, Eggermont AM, Flaherty KT, Garbe C, Goldstein AM, Halpern A, Kashani-Sabet M, Hauschild A, Kirkwood JM, Leachman S, Lorigan P, McMahon M, Messina J, Ribas A, Samlowski WE, Schadendorf D, Sondak VK. Agarwala SS, et al. Among authors: flaherty kt. Pigment Cell Melanoma Res. 2009 Oct;22(5):532-43. doi: 10.1111/j.1755-148X.2009.00602.x. Epub 2009 Jun 29. Pigment Cell Melanoma Res. 2009. PMID: 19659612

7

Development of a novel chemical class of BRAF inhibitors offers new hope for melanoma treatment.

Smalley KS, Flaherty KT. Smalley KS, et al. Among authors: flaherty kt. Future Oncol. 2009 Aug;5(6):775-8. doi: 10.2217/fon.09.56. Future Oncol. 2009. PMID: 19663727

8

Advances in drug development. BRAF validation in melanoma.

Flaherty K. Flaherty K. Clin Adv Hematol Oncol. 2010 Jan;8(1):31-4. Clin Adv Hematol Oncol. 2010. PMID: 20351680 No abstract available.

9

Mutation-driven drug development in melanoma.

Flaherty KT, Hodi FS, Bastian BC. Flaherty KT, et al. Curr Opin Oncol. 2010 May;22(3):178-83. doi: 10.1097/cco.0b013e32833888ee. Curr Opin Oncol. 2010. PMID: 20401974 Free PMC article. Review.

10

Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function.

Boni A, Cogdill AP, Dang P, Udayakumar D, Njauw CN, Sloss CM, Ferrone CR, Flaherty KT, Lawrence DP, Fisher DE, Tsao H, Wargo JA. Boni A, et al. Among authors: flaherty kt. Cancer Res. 2010 Jul 1;70(13):5213-9. doi: 10.1158/0008-5472.CAN-10-0118. Epub 2010 Jun 15. Cancer Res. 2010. PMID: 20551059

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