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A refined atomic scale model of the Saccharomyces cerevisiae K+-translocation protein Trk1p combined with experimental evidence confirms the role of selectivity filter glycines and other key residues.
Zayats V, Stockner T, Pandey SK, Wörz K, Ettrich R, Ludwig J. Zayats V, et al. Among authors: ettrich r. Biochim Biophys Acta. 2015 May;1848(5):1183-95. doi: 10.1016/j.bbamem.2015.02.007. Epub 2015 Feb 14. Biochim Biophys Acta. 2015. PMID: 25687974 Free article.
Communication between N terminus and loop2 tunes Orai activation.
Fahrner M, Pandey SK, Muik M, Traxler L, Butorac C, Stadlbauer M, Zayats V, Krizova A, Plenk P, Frischauf I, Schindl R, Gruber HJ, Hinterdorfer P, Ettrich R, Romanin C, Derler I. Fahrner M, et al. Among authors: ettrich r. J Biol Chem. 2018 Jan 26;293(4):1271-1285. doi: 10.1074/jbc.M117.812693. Epub 2017 Dec 13. J Biol Chem. 2018. PMID: 29237733 Free PMC article.
A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription.
Frischauf I, Zayats V, Deix M, Hochreiter A, Jardin I, Muik M, Lackner B, Svobodová B, Pammer T, Litviňuková M, Sridhar AA, Derler I, Bogeski I, Romanin C, Ettrich RH, Schindl R. Frischauf I, et al. Among authors: ettrich rh. Sci Signal. 2015 Dec 22;8(408):ra131. doi: 10.1126/scisignal.aab1901. Sci Signal. 2015. PMID: 26696631 Free PMC article.
Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.
Frischauf I, Litviňuková M, Schober R, Zayats V, Svobodová B, Bonhenry D, Lunz V, Cappello S, Tociu L, Reha D, Stallinger A, Hochreiter A, Pammer T, Butorac C, Muik M, Groschner K, Bogeski I, Ettrich RH, Romanin C, Schindl R. Frischauf I, et al. Among authors: ettrich rh. Sci Signal. 2017 Nov 28;10(507):eaao0358. doi: 10.1126/scisignal.aao0358. Sci Signal. 2017. PMID: 29184031 Free PMC article.
67 results