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Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers.
Chinsangaram J, Honeychurch KM, Tyavanagimatt SR, Leeds JM, Bolken TC, Jones KF, Jordan R, Marbury T, Ruckle J, Mee-Lee D, Ross E, Lichtenstein I, Pickens M, Corrado M, Clarke JM, Frimm AM, Hruby DE. Chinsangaram J, et al. Among authors: leeds jm. Antimicrob Agents Chemother. 2012 Sep;56(9):4900-5. doi: 10.1128/AAC.00904-12. Epub 2012 Jul 9. Antimicrob Agents Chemother. 2012. PMID: 22777041 Free PMC article. Clinical Trial.
Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys.
Chen Y, Amantana A, Tyavanagimatt SR, Zima D, Yan XS, Kasi G, Weeks M, Stone MA, Weimers WC, Samuel P, Tan Y, Jones KF, Lee DR, Kickner SS, Saville BM, Lauzon M, McIntyre A, Honeychurch KM, Jordan R, Hruby DE, Leeds JM. Chen Y, et al. Among authors: leeds jm. PLoS One. 2011;6(8):e23237. doi: 10.1371/journal.pone.0023237. Epub 2011 Aug 15. PLoS One. 2011. PMID: 21858040 Free PMC article.
Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans.
Leeds JM, Fenneteau F, Gosselin NH, Mouksassi MS, Kassir N, Marier JF, Chen Y, Grosenbach D, Frimm AE, Honeychurch KM, Chinsangaram J, Tyavanagimatt SR, Hruby DE, Jordan R. Leeds JM, et al. Antimicrob Agents Chemother. 2013 Mar;57(3):1136-43. doi: 10.1128/AAC.00959-12. Epub 2012 Dec 17. Antimicrob Agents Chemother. 2013. PMID: 23254433 Free PMC article.
Development of ST-246® for Treatment of Poxvirus Infections.
Jordan R, Leeds JM, Tyavanagimatt S, Hruby DE. Jordan R, et al. Among authors: leeds jm. Viruses. 2010 Nov;2(11):2409-2435. doi: 10.3390/v2112409. Epub 2010 Nov 3. Viruses. 2010. PMID: 21994624 Free PMC article.
Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase.
Byrd CM, Grosenbach DW, Berhanu A, Dai D, Jones KF, Cardwell KB, Schneider C, Yang G, Tyavanagimatt S, Harver C, Wineinger KA, Page J, Stavale E, Stone MA, Fuller KP, Lovejoy C, Leeds JM, Hruby DE, Jordan R. Byrd CM, et al. Among authors: leeds jm. Antimicrob Agents Chemother. 2013 Apr;57(4):1902-12. doi: 10.1128/AAC.02251-12. Epub 2013 Feb 12. Antimicrob Agents Chemother. 2013. PMID: 23403421 Free PMC article.
44 results