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IFITM3 restricts the morbidity and mortality associated with influenza.
Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB; GenISIS Investigators; MOSAIC Investigators; Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P. Everitt AR, et al. Nature. 2012 Mar 25;484(7395):519-23. doi: 10.1038/nature10921. Nature. 2012. PMID: 22446628 Free PMC article.
Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility.
Shelton H, Roberts KL, Molesti E, Temperton N, Barclay WS. Shelton H, et al. Among authors: barclay ws. J Gen Virol. 2013 Jun;94(Pt 6):1220-1229. doi: 10.1099/vir.0.050526-0. Epub 2013 Mar 13. J Gen Virol. 2013. PMID: 23486663 Free PMC article.
Harnessing alveolar macrophages for sustained mucosal T-cell recall confers long-term protection to mice against lethal influenza challenge without clinical disease.
Macdonald DC, Singh H, Whelan MA, Escors D, Arce F, Bottoms SE, Barclay WS, Maini M, Collins MK, Rosenberg WM. Macdonald DC, et al. Among authors: barclay ws. Mucosal Immunol. 2014 Jan;7(1):89-100. doi: 10.1038/mi.2013.27. Epub 2013 May 29. Mucosal Immunol. 2014. PMID: 23715172 Free article.
282 results