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Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes.
van Doorn R, Nijland PG, Dekker N, Witte ME, Lopes-Pinheiro MA, van het Hof B, Kooij G, Reijerkerk A, Dijkstra C, van van der Valk P, van Horssen J, de Vries HE. van Doorn R, et al. Among authors: lopes pinheiro ma. Acta Neuropathol. 2012 Sep;124(3):397-410. doi: 10.1007/s00401-012-1014-4. Epub 2012 Jul 19. Acta Neuropathol. 2012. PMID: 22810490
Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier.
van Doorn R, Lopes Pinheiro MA, Kooij G, Lakeman K, van het Hof B, van der Pol SM, Geerts D, van Horssen J, van der Valk P, van der Kam E, Ronken E, Reijerkerk A, de Vries HE. van Doorn R, et al. Among authors: lopes pinheiro ma. J Neuroinflammation. 2012 Jun 20;9:133. doi: 10.1186/1742-2094-9-133. J Neuroinflammation. 2012. PMID: 22715976 Free PMC article.
Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner.
Derada Troletti C, Lopes Pinheiro MA, Charabati M, Gowing E, van Het Hof B, van der Pol SMA, Geerts D, Prat A, Fontijn RD, Unger WW, de Vries HE. Derada Troletti C, et al. Among authors: lopes pinheiro ma. Brain Behav Immun. 2018 Mar;69:48-56. doi: 10.1016/j.bbi.2017.12.016. Epub 2017 Dec 28. Brain Behav Immun. 2018. PMID: 29289661
Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis.
Leurs CE, Lopes Pinheiro MA, Wierts L, den Hoedt S, Mulder MT, Eijlers AJC, Schoonheim MM, Balk LJ, Uitdehaag BMJ, Killestein J, de Vries HE. Leurs CE, et al. Among authors: lopes pinheiro ma. Mult Scler Relat Disord. 2019 Feb;28:44-49. doi: 10.1016/j.msard.2018.11.024. Epub 2018 Nov 30. Mult Scler Relat Disord. 2019. PMID: 30553168