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Proprotein convertase subtilisin/kexin type 9 inhibition.
Marais DA, Blom DJ, Petrides F, Gouëffic Y, Lambert G. Marais DA, et al. Among authors: blom dj. Curr Opin Lipidol. 2012 Dec;23(6):511-7. doi: 10.1097/MOL.0b013e3283587563. Curr Opin Lipidol. 2012. PMID: 22907332 Review.
Elevated plasma PCSK9 level is equally detrimental for patients with nonfamilial hypercholesterolemia and heterozygous familial hypercholesterolemia, irrespective of low-density lipoprotein receptor defects.
Lambert G, Petrides F, Chatelais M, Blom DJ, Choque B, Tabet F, Wong G, Rye KA, Hooper AJ, Burnett JR, Barter PJ, Marais AD. Lambert G, et al. Among authors: blom dj. J Am Coll Cardiol. 2014 Jun 10;63(22):2365-73. doi: 10.1016/j.jacc.2014.02.538. Epub 2014 Mar 12. J Am Coll Cardiol. 2014. PMID: 24632287 Free article.
Normalization of low-density lipoprotein receptor expression in receptor defective homozygous familial hypercholesterolemia by inhibition of PCSK9 with alirocumab.
Lambert G, Chatelais M, Petrides F, Passard M, Thedrez A, Rye KA, Schwahn U, Gusarova V, Blom DJ, Sasiela W, Marais AD. Lambert G, et al. Among authors: blom dj. J Am Coll Cardiol. 2014 Dec 2;64(21):2299-300. doi: 10.1016/j.jacc.2014.07.995. Epub 2014 Nov 24. J Am Coll Cardiol. 2014. PMID: 25456764 Free article. No abstract available.
Homozygous Familial Hypercholesterolemia Patients With Identical Mutations Variably Express the LDLR (Low-Density Lipoprotein Receptor): Implications for the Efficacy of Evolocumab.
Thedrez A, Blom DJ, Ramin-Mangata S, Blanchard V, Croyal M, Chemello K, Nativel B, Pichelin M, Cariou B, Bourane S, Tang L, Farnier M, Raal FJ, Lambert G. Thedrez A, et al. Among authors: blom dj. Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):592-598. doi: 10.1161/ATVBAHA.117.310217. Epub 2017 Dec 28. Arterioscler Thromb Vasc Biol. 2018. PMID: 29284604 Free PMC article. Clinical Trial.
PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo: An Effect Blunted by Alirocumab.
Villard EF, Thedrez A, Blankenstein J, Croyal M, Tran TT, Poirier B, Le Bail JC, Illiano S, Nobécourt E, Krempf M, Blom DJ, Marais AD, Janiak P, Muslin AJ, Guillot E, Lambert G. Villard EF, et al. Among authors: blom dj. JACC Basic Transl Sci. 2016 Oct;1(6):419-427. doi: 10.1016/j.jacbts.2016.06.006. JACC Basic Transl Sci. 2016. PMID: 29308438 Free PMC article.
Low-density lipoprotein cholesterol goal achievement in patients with familial hypercholesterolemia in countries outside Western Europe: The International ChoLesterol management Practice Study.
Blom DJ, Almahmeed W, Al-Rasadi K, Azuri J, Daclin V, Kayikcioglu M, Mercier F, Ruiz AJ, Santos RD; ICLPS study group. Blom DJ, et al. J Clin Lipidol. 2019 Jul-Aug;13(4):594-600. doi: 10.1016/j.jacl.2019.05.004. Epub 2019 May 14. J Clin Lipidol. 2019. PMID: 31208705 Free article. Clinical Trial.
Novel PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Variants in Patients With Familial Hypercholesterolemia From Cape Town.
Huijgen R, Blom DJ, Hartgers ML, Chemello K, Benito-Vicente A, Uribe KB, Behardien Z, Blackhurst DM, Brice BC, Defesche JC, de Jong AG, Jooste RJ, Solomon GAE, Wolmarans KH, Hovingh GK, Martin C, Lambert G, Marais AD. Huijgen R, et al. Among authors: blom dj. Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):934-943. doi: 10.1161/ATVBAHA.120.314482. Epub 2020 Nov 5. Arterioscler Thromb Vasc Biol. 2021. PMID: 33147992 Free article.
99 results