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Quantitative approaches for assessing dose-response relationships in genetic toxicology studies.
Gollapudi BB, Johnson GE, Hernandez LG, Pottenger LH, Dearfield KL, Jeffrey AM, Julien E, Kim JH, Lovell DP, Macgregor JT, Moore MM, van Benthem J, White PA, Zeiger E, Thybaud V. Gollapudi BB, et al. Among authors: dearfield kl. Environ Mol Mutagen. 2013 Jan;54(1):8-18. doi: 10.1002/em.21727. Epub 2012 Sep 18. Environ Mol Mutagen. 2013. PMID: 22987251
Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations.
Dearfield KL, Gollapudi BB, Bemis JC, Benz RD, Douglas GR, Elespuru RK, Johnson GE, Kirkland DJ, LeBaron MJ, Li AP, Marchetti F, Pottenger LH, Rorije E, Tanir JY, Thybaud V, van Benthem J, Yauk CL, Zeiger E, Luijten M. Dearfield KL, et al. Environ Mol Mutagen. 2017 Jun;58(5):264-283. doi: 10.1002/em.22045. Epub 2016 Sep 21. Environ Mol Mutagen. 2017. PMID: 27650663 Review.
Utility of a next generation framework for assessment of genomic damage: A case study using the industrial chemical benzene.
Luijten M, Ball NS, Dearfield KL, Gollapudi BB, Johnson GE, Madia F, Peel L, Pfuhler S, Settivari RS, Ter Burg W, White PA, van Benthem J. Luijten M, et al. Among authors: dearfield kl. Environ Mol Mutagen. 2020 Jan;61(1):94-113. doi: 10.1002/em.22346. Epub 2019 Nov 27. Environ Mol Mutagen. 2020. PMID: 31709603 Free PMC article. Review.
Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment.
Johnson GE, Soeteman-Hernández LG, Gollapudi BB, Bodger OG, Dearfield KL, Heflich RH, Hixon JG, Lovell DP, MacGregor JT, Pottenger LH, Thompson CM, Abraham L, Thybaud V, Tanir JY, Zeiger E, van Benthem J, White PA. Johnson GE, et al. Among authors: dearfield kl. Environ Mol Mutagen. 2014 Oct;55(8):609-23. doi: 10.1002/em.21870. Epub 2014 May 6. Environ Mol Mutagen. 2014. PMID: 24801602 Free PMC article.
Follow-up actions from positive results of in vitro genetic toxicity testing.
Dearfield KL, Thybaud V, Cimino MC, Custer L, Czich A, Harvey JS, Hester S, Kim JH, Kirkland D, Levy DD, Lorge E, Moore MM, Ouédraogo-Arras G, Schuler M, Suter W, Sweder K, Tarlo K, van Benthem J, van Goethem F, Witt KL. Dearfield KL, et al. Environ Mol Mutagen. 2011 Apr;52(3):177-204. doi: 10.1002/em.20617. Epub 2010 Oct 20. Environ Mol Mutagen. 2011. PMID: 20963811 Free article. Review.
Application of the adverse outcome pathway framework to genotoxic modes of action.
Sasaki JC, Allemang A, Bryce SM, Custer L, Dearfield KL, Dietz Y, Elhajouji A, Escobar PA, Fornace AJ Jr, Froetschl R, Galloway S, Hemmann U, Hendriks G, Li HH, Luijten M, Ouedraogo G, Peel L, Pfuhler S, Roberts DJ, Thybaud V, van Benthem J, Yauk CL, Schuler M. Sasaki JC, et al. Among authors: dearfield kl. Environ Mol Mutagen. 2020 Jan;61(1):114-134. doi: 10.1002/em.22339. Epub 2019 Oct 31. Environ Mol Mutagen. 2020. PMID: 31603995
Strategies in case of positive in vivo results in genotoxicity testing.
Thybaud V, Macgregor JT, Müller L, Crebelli R, Dearfield K, Douglas G, Farmer PB, Gocke E, Hayashi M, Lovell DP, Lutz WK, Marzin D, Moore M, Nohmi T, Phillips DH, Van Benthem J. Thybaud V, et al. Mutat Res. 2011 Aug 16;723(2):121-8. doi: 10.1016/j.mrgentox.2010.09.002. Epub 2010 Sep 17. Mutat Res. 2011. PMID: 20854927
Utility of a next-generation framework for assessment of genomic damage: A case study using the pharmaceutical drug candidate etoposide.
Nicolette J, Luijten M, Sasaki JC, Custer L, Embry M, Froetschl R, Johnson G, Ouedraogo G, Settivari R, Thybaud V, Dearfield KL. Nicolette J, et al. Among authors: dearfield kl. Environ Mol Mutagen. 2021 Nov;62(9):512-525. doi: 10.1002/em.22467. Epub 2021 Nov 22. Environ Mol Mutagen. 2021. PMID: 34775645 Free PMC article. Review.
70 results