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Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.
Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC. Ehre C, et al. Among authors: sallenave jm. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16528-33. doi: 10.1073/pnas.1206552109. Epub 2012 Sep 24. Proc Natl Acad Sci U S A. 2012. PMID: 23012413 Free PMC article.
Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing.
Descamps D, Le Gars M, Balloy V, Barbier D, Maschalidi S, Tohme M, Chignard M, Ramphal R, Manoury B, Sallenave JM. Descamps D, et al. Among authors: sallenave jm. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1619-24. doi: 10.1073/pnas.1108464109. Epub 2012 Jan 17. Proc Natl Acad Sci U S A. 2012. PMID: 22307620 Free PMC article.
Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.
Barbier D, Garcia-Verdugo I, Pothlichet J, Khazen R, Descamps D, Rousseau K, Thornton D, Si-Tahar M, Touqui L, Chignard M, Sallenave JM. Barbier D, et al. Among authors: sallenave jm. Am J Respir Cell Mol Biol. 2012 Aug;47(2):149-57. doi: 10.1165/rcmb.2011-0405OC. Epub 2012 Mar 1. Am J Respir Cell Mol Biol. 2012. PMID: 22383584
Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo.
Le Gars M, Descamps D, Roussel D, Saussereau E, Guillot L, Ruffin M, Tabary O, Hong SS, Boulanger P, Paulais M, Malleret L, Belaaouaj A, Edelman A, Huerre M, Chignard M, Sallenave JM. Le Gars M, et al. Among authors: sallenave jm. Am J Respir Crit Care Med. 2013 Jan 15;187(2):170-9. doi: 10.1164/rccm.201205-0875OC. Epub 2012 Dec 6. Am J Respir Crit Care Med. 2013. PMID: 23220915
Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway.
Balloy V, Sallenave JM, Wu Y, Touqui L, Latgé JP, Si-Tahar M, Chignard M. Balloy V, et al. Among authors: sallenave jm. J Biol Chem. 2008 Nov 7;283(45):30513-21. doi: 10.1074/jbc.M803149200. Epub 2008 Aug 14. J Biol Chem. 2008. PMID: 18703508 Free PMC article.
105 results