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The angiogenic factor secretoneurin induces coronary angiogenesis in a model of myocardial infarction by stimulation of vascular endothelial growth factor signaling in endothelial cells.
Albrecht-Schgoer K, Schgoer W, Holfeld J, Theurl M, Wiedemann D, Steger C, Gupta R, Semsroth S, Fischer-Colbrie R, Beer AG, Stanzl U, Huber E, Misener S, Dejaco D, Kishore R, Pachinger O, Grimm M, Bonaros N, Kirchmair R. Albrecht-Schgoer K, et al. Circulation. 2012 Nov 20;126(21):2491-501. doi: 10.1161/CIRCULATIONAHA.111.076950. Epub 2012 Oct 18. Circulation. 2012. PMID: 23081990 Free PMC article.
Hypoxia up-regulates the angiogenic cytokine secretoneurin via an HIF-1alpha- and basic FGF-dependent pathway in muscle cells.
Egger M, Schgoer W, Beer AG, Jeschke J, Leierer J, Theurl M, Frauscher S, Tepper OM, Niederwanger A, Ritsch A, Kearney M, Wanschitz J, Gurtner GC, Fischer-Colbrie R, Weiss G, Piza-Katzer H, Losordo DW, Patsch JR, Schratzberger P, Kirchmair R. Egger M, et al. FASEB J. 2007 Sep;21(11):2906-17. doi: 10.1096/fj.06-7440com. Epub 2007 May 15. FASEB J. 2007. PMID: 17504977
Gene therapy with the angiogenic cytokine secretoneurin induces therapeutic angiogenesis by a nitric oxide-dependent mechanism.
Schgoer W, Theurl M, Jeschke J, Beer AG, Albrecht K, Gander R, Rong S, Vasiljevic D, Egger M, Wolf AM, Frauscher S, Koller B, Tancevski I, Patsch JR, Schratzberger P, Piza-Katzer H, Ritsch A, Bahlmann FH, Fischer-Colbrie R, Wolf D, Kirchmair R. Schgoer W, et al. Circ Res. 2009 Nov 6;105(10):994-1002. doi: 10.1161/CIRCRESAHA.109.199513. Epub 2009 Oct 1. Circ Res. 2009. PMID: 19797703
Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E⁻/⁻ mice without influencing systemic atherosclerosis.
Theurl M, Schgoer W, Albrecht-Schgoer K, Lener D, Wolf D, Wolf M, Demetz E, Tymoszuk P, Tancevski I, Fischer-Colbrie R, Franz WM, Marschang P, Kirchmair R. Theurl M, et al. Among authors: fischer colbrie r. Cardiovasc Res. 2015 Jan 1;105(1):96-106. doi: 10.1093/cvr/cvu237. Epub 2014 Nov 5. Cardiovasc Res. 2015. PMID: 25377726
The neuropeptide secretoneurin acts as a direct angiogenic cytokine in vitro and in vivo.
Kirchmair R, Gander R, Egger M, Hanley A, Silver M, Ritsch A, Murayama T, Kaneider N, Sturm W, Kearny M, Fischer-Colbrie R, Kircher B, Gaenzer H, Wiedermann CJ, Ropper AH, Losordo DW, Patsch JR, Schratzberger P. Kirchmair R, et al. Circulation. 2004 Feb 17;109(6):777-83. doi: 10.1161/01.CIR.0000112574.07422.C1. Circulation. 2004. PMID: 14970115
Secretoneurin, an angiogenic neuropeptide, induces postnatal vasculogenesis.
Kirchmair R, Egger M, Walter DH, Eisterer W, Niederwanger A, Woell E, Nagl M, Pedrini M, Murayama T, Frauscher S, Hanley A, Silver M, Brodmann M, Sturm W, Fischer-Colbrie R, Losordo DW, Patsch JR, Schratzberger P. Kirchmair R, et al. Circulation. 2004 Aug 31;110(9):1121-7. doi: 10.1161/01.CIR.0000139884.81390.56. Epub 2004 Aug 23. Circulation. 2004. PMID: 15326074
205 results