Gardner OS - Search Results

1

Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor.

Kim KB, Kefford R, Pavlick AC, Infante JR, Ribas A, Sosman JA, Fecher LA, Millward M, McArthur GA, Hwu P, Gonzalez R, Ott PA, Long GV, Gardner OS, Ouellet D, Xu Y, DeMarini DJ, Le NT, Patel K, Lewis KD. Kim KB, et al. Among authors: gardner os. J Clin Oncol. 2013 Feb 1;31(4):482-9. doi: 10.1200/JCO.2012.43.5966. Epub 2012 Dec 17. J Clin Oncol. 2013. PMID: 23248257 Free PMC article. Clinical Trial.

2

Population pharmacokinetics and exposure-response of trametinib, a MEK inhibitor, in patients with BRAF V600 mutation-positive melanoma.

Ouellet D, Kassir N, Chiu J, Mouksassi MS, Leonowens C, Cox D, DeMarini DJ, Gardner O, Crist W, Patel K. Ouellet D, et al. Cancer Chemother Pharmacol. 2016 Apr;77(4):807-17. doi: 10.1007/s00280-016-2993-y. Epub 2016 Mar 3. Cancer Chemother Pharmacol. 2016. PMID: 26940938 Clinical Trial.

3

A Phase 1/1b Study Evaluating Trametinib Plus Docetaxel or Pemetrexed in Patients With Advanced Non-Small Cell Lung Cancer.

Gandara DR, Leighl N, Delord JP, Barlesi F, Bennouna J, Zalcman G, Infante JR, Reckamp KL, Kelly K, Shepherd FA, Mazieres J, Janku F, Gardner OS, Mookerjee B, Wu Y, Cox DS, Schramek D, Peddareddigari V, Liu Y, D'Amelio AM Jr, Blumenschein G Jr. Gandara DR, et al. Among authors: gardner os. J Thorac Oncol. 2017 Mar;12(3):556-566. doi: 10.1016/j.jtho.2016.11.2218. Epub 2016 Nov 19. J Thorac Oncol. 2017. PMID: 27876675 Free article. Clinical Trial.

4

A dose-escalation study of recombinant human interleukin-18 in combination with rituximab in patients with non-Hodgkin lymphoma.

Robertson MJ, Kline J, Struemper H, Koch KM, Bauman JW, Gardner OS, Murray SC, Germaschewski F, Weisenbach J, Jonak Z, Toso JF. Robertson MJ, et al. Among authors: gardner os. J Immunother. 2013 Jul-Aug;36(6):331-41. doi: 10.1097/CJI.0b013e31829d7e2e. J Immunother. 2013. PMID: 23799412 Free PMC article. Clinical Trial.

5

Chemoimmunotherapy using pegylated liposomal Doxorubicin and interleukin-18 in recurrent ovarian cancer: a phase I dose-escalation study.

Simpkins F, Flores A, Chu C, Berek JS, Lucci J 3rd, Murray S, Bauman J, Struemper H, Germaschewski F, Jonak Z, Gardner O, Toso J, Coukos G. Simpkins F, et al. Cancer Immunol Res. 2013 Sep;1(3):168-78. doi: 10.1158/2326-6066.CIR-13-0098. Epub 2013 Jul 31. Cancer Immunol Res. 2013. PMID: 24777679 Clinical Trial.

6

Capacitative calcium entry contributes to the differential transactivation of the epidermal growth factor receptor in response to thiazolidinediones.

Dewar BJ, Gardner OS, Chen CS, Earp HS, Samet JM, Graves LM. Dewar BJ, et al. Among authors: gardner os. Mol Pharmacol. 2007 Nov;72(5):1146-56. doi: 10.1124/mol.107.037549. Epub 2007 Aug 8. Mol Pharmacol. 2007. PMID: 17686966

7

Activation of mitogen-activated protein kinases by peroxisome proliferator-activated receptor ligands: an example of nongenomic signaling.

Gardner OS, Dewar BJ, Graves LM. Gardner OS, et al. Mol Pharmacol. 2005 Oct;68(4):933-41. doi: 10.1124/mol.105.012260. Epub 2005 Jul 14. Mol Pharmacol. 2005. PMID: 16020742 Review.

8

Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation.

Gardner OS, Dewar BJ, Earp HS, Samet JM, Graves LM. Gardner OS, et al. J Biol Chem. 2003 Nov 21;278(47):46261-9. doi: 10.1074/jbc.M307827200. Epub 2003 Sep 9. J Biol Chem. 2003. PMID: 12966092 Free article.

9

Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.

Gardner OS, Shiau CW, Chen CS, Graves LM. Gardner OS, et al. J Biol Chem. 2005 Mar 18;280(11):10109-18. doi: 10.1074/jbc.M410445200. Epub 2005 Jan 13. J Biol Chem. 2005. PMID: 15649892 Free article.

10

Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif.

Yohe ME, Rossman KL, Gardner OS, Karnoub AE, Snyder JT, Gershburg S, Graves LM, Der CJ, Sondek J. Yohe ME, et al. Among authors: gardner os. J Biol Chem. 2007 May 4;282(18):13813-23. doi: 10.1074/jbc.M700185200. Epub 2007 Mar 2. J Biol Chem. 2007. PMID: 17337446 Free article.

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