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Designing an adaptive phase II/III trial to evaluate efficacy, safety and immune correlates of new TB vaccines in young adults and adolescents.
Rustomjee R, McClain B, Brennan MJ, McLeod R, Chetty-Makkan CM, McShane H, Hanekom W, Steel G, Mahomed H, Ginsberg AM, Shea J, Lockhart S, Self S, Churchyard GJ. Rustomjee R, et al. Among authors: lockhart s. Tuberculosis (Edinb). 2013 Mar;93(2):136-42. doi: 10.1016/j.tube.2012.11.005. Epub 2012 Dec 23. Tuberculosis (Edinb). 2013. PMID: 23266259
Key issues in the clinical development and implementation of TB vaccines in South Africa.
Rustomjee R, Mcleod R, Hanekom W, Steel G, Mahomed H, Hawkridge A, Welte A, Sinanovic E, Loots G, Grobler A, Mvusi L, Gray G, Hesseling A, Ginsberg A, Lienhardt C, Shea J, Tong X, Lockhart S, Churchyard GJ. Rustomjee R, et al. Among authors: lockhart s. Tuberculosis (Edinb). 2012 Sep;92(5):359-64. doi: 10.1016/j.tube.2012.05.001. Epub 2012 Jun 12. Tuberculosis (Edinb). 2012. PMID: 22698868
Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial.
Tameris MD, Hatherill M, Landry BS, Scriba TJ, Snowden MA, Lockhart S, Shea JE, McClain JB, Hussey GD, Hanekom WA, Mahomed H, McShane H; MVA85A 020 Trial Study Team. Tameris MD, et al. Among authors: lockhart s. Lancet. 2013 Mar 23;381(9871):1021-8. doi: 10.1016/S0140-6736(13)60177-4. Lancet. 2013. PMID: 23391465 Free PMC article. Clinical Trial.
Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG.
Tameris M, McShane H, McClain JB, Landry B, Lockhart S, Luabeya AK, Geldenhuys H, Shea J, Hussey G, van der Merwe L, de Kock M, Scriba T, Walker R, Hanekom W, Hatherill M, Mahomed H. Tameris M, et al. Among authors: lockhart s. Tuberculosis (Edinb). 2013 Mar;93(2):143-9. doi: 10.1016/j.tube.2013.01.003. Epub 2013 Feb 12. Tuberculosis (Edinb). 2013. PMID: 23410889 Free PMC article. Clinical Trial.
Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a.
Darton TC, Jones C, Blohmke CJ, Waddington CS, Zhou L, Peters A, Haworth K, Sie R, Green CA, Jeppesen CA, Moore M, Thompson BA, John T, Kingsley RA, Yu LM, Voysey M, Hindle Z, Lockhart S, Sztein MB, Dougan G, Angus B, Levine MM, Pollard AJ. Darton TC, et al. Among authors: lockhart s. PLoS Negl Trop Dis. 2016 Aug 17;10(8):e0004926. doi: 10.1371/journal.pntd.0004926. eCollection 2016 Aug. PLoS Negl Trop Dis. 2016. PMID: 27533046 Free PMC article. Clinical Trial.
Conjugate vaccines.
Lockhart S. Lockhart S. Expert Rev Vaccines. 2003 Oct;2(5):633-48. doi: 10.1586/14760584.2.5.633. Expert Rev Vaccines. 2003. PMID: 14711325 Review.
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