Lyon AM - Search Results

1

Full-length Gα(q)-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain.

Lyon AM, Dutta S, Boguth CA, Skiniotis G, Tesmer JJ. Lyon AM, et al. Nat Struct Mol Biol. 2013 Mar;20(3):355-62. doi: 10.1038/nsmb.2497. Epub 2013 Feb 3. Nat Struct Mol Biol. 2013. PMID: 23377541 Free PMC article.

2

An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation.

Lyon AM, Tesmer VM, Dhamsania VD, Thal DM, Gutierrez J, Chowdhury S, Suddala KC, Northup JK, Tesmer JJ. Lyon AM, et al. Nat Struct Mol Biol. 2011 Aug 7;18(9):999-1005. doi: 10.1038/nsmb.2095. Nat Struct Mol Biol. 2011. PMID: 21822282 Free PMC article.

3

Structural insights into phospholipase C-β function.

Lyon AM, Tesmer JJ. Lyon AM, et al. Mol Pharmacol. 2013 Oct;84(4):488-500. doi: 10.1124/mol.113.087403. Epub 2013 Jul 23. Mol Pharmacol. 2013. PMID: 23880553 Free PMC article. Review.

4

Strike a pose: Gαq complexes at the membrane.

Lyon AM, Taylor VG, Tesmer JJ. Lyon AM, et al. Trends Pharmacol Sci. 2014 Jan;35(1):23-30. doi: 10.1016/j.tips.2013.10.008. Epub 2013 Nov 26. Trends Pharmacol Sci. 2014. PMID: 24287282 Free PMC article. Review.

5

Molecular mechanisms of phospholipase C β3 autoinhibition.

Lyon AM, Begley JA, Manett TD, Tesmer JJG. Lyon AM, et al. Structure. 2014 Dec 2;22(12):1844-1854. doi: 10.1016/j.str.2014.10.008. Structure. 2014. PMID: 25435326 Free PMC article.

6

Structure of phospholipase Cε reveals an integrated RA1 domain and previously unidentified regulatory elements.

Rugema NY, Garland-Kuntz EE, Sieng M, Muralidharan K, Van Camp MM, O'Neill H, Mbongo W, Selvia AF, Marti AT, Everly A, McKenzie E, Lyon AM. Rugema NY, et al. Among authors: lyon am. Commun Biol. 2020 Aug 14;3(1):445. doi: 10.1038/s42003-020-01178-8. Commun Biol. 2020. PMID: 32796910 Free PMC article.

7

G protein βγ subunits directly interact with and activate phospholipase Cϵ.

Madukwe JC, Garland-Kuntz EE, Lyon AM, Smrcka AV. Madukwe JC, et al. Among authors: lyon am. J Biol Chem. 2018 Apr 27;293(17):6387-6397. doi: 10.1074/jbc.RA118.002354. Epub 2018 Mar 13. J Biol Chem. 2018. PMID: 29535186 Free PMC article.

8

Q's the Boss: Gα_q Regulates G_i-Mediated Calcium Release through PLCβ.

Fisher IJ, Lyon AM. Fisher IJ, et al. Among authors: lyon am. Mol Cell. 2020 Dec 17;80(6):933-934. doi: 10.1016/j.molcel.2020.11.038. Mol Cell. 2020. PMID: 33338407 Free article.

9

Structure and regulation of phospholipase Cβ and ε at the membrane.

Muralidharan K, Van Camp MM, Lyon AM. Muralidharan K, et al. Among authors: lyon am. Chem Phys Lipids. 2021 Mar;235:105050. doi: 10.1016/j.chemphyslip.2021.105050. Epub 2021 Jan 7. Chem Phys Lipids. 2021. PMID: 33422547 Free PMC article. Review.

10

Phospholipase Cβ3 Membrane Adsorption and Activation Are Regulated by Its C-Terminal Domains and Phosphatidylinositol 4,5-Bisphosphate.

Hudson BN, Hyun SH, Thompson DH, Lyon AM. Hudson BN, et al. Among authors: lyon am. Biochemistry. 2017 Oct 17;56(41):5604-5614. doi: 10.1021/acs.biochem.7b00547. Epub 2017 Oct 5. Biochemistry. 2017. PMID: 28945350

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