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Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase.
Byrd CM, Grosenbach DW, Berhanu A, Dai D, Jones KF, Cardwell KB, Schneider C, Yang G, Tyavanagimatt S, Harver C, Wineinger KA, Page J, Stavale E, Stone MA, Fuller KP, Lovejoy C, Leeds JM, Hruby DE, Jordan R. Byrd CM, et al. Among authors: jordan r. Antimicrob Agents Chemother. 2013 Apr;57(4):1902-12. doi: 10.1128/AAC.02251-12. Epub 2013 Feb 12. Antimicrob Agents Chemother. 2013. PMID: 23403421 Free PMC article.
ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification.
Jordan R, Goff A, Frimm A, Corrado ML, Hensley LE, Byrd CM, Mucker E, Shamblin J, Bolken TC, Wlazlowski C, Johnson W, Chapman J, Twenhafel N, Tyavanagimatt S, Amantana A, Chinsangaram J, Hruby DE, Huggins J. Jordan R, et al. Antimicrob Agents Chemother. 2009 May;53(5):1817-22. doi: 10.1128/AAC.01596-08. Epub 2009 Feb 17. Antimicrob Agents Chemother. 2009. PMID: 19223621 Free PMC article. Clinical Trial.
A novel inhibitor of dengue virus replication that targets the capsid protein.
Byrd CM, Dai D, Grosenbach DW, Berhanu A, Jones KF, Cardwell KB, Schneider C, Wineinger KA, Page JM, Harver C, Stavale E, Tyavanagimatt S, Stone MA, Bartenschlager R, Scaturro P, Hruby DE, Jordan R. Byrd CM, et al. Among authors: jordan r. Antimicrob Agents Chemother. 2013 Jan;57(1):15-25. doi: 10.1128/AAC.01429-12. Epub 2012 Oct 15. Antimicrob Agents Chemother. 2013. PMID: 23070172 Free PMC article.
Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice.
Grosenbach DW, Berhanu A, King DS, Mosier S, Jones KF, Jordan RA, Bolken TC, Hruby DE. Grosenbach DW, et al. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):838-43. doi: 10.1073/pnas.0912134107. Epub 2009 Dec 22. Proc Natl Acad Sci U S A. 2010. PMID: 20080762 Free PMC article.
Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects.
Jordan R, Chinsangaram J, Bolken TC, Tyavanagimatt SR, Tien D, Jones KF, Frimm A, Corrado ML, Pickens M, Landis P, Clarke J, Marbury TC, Hruby DE. Jordan R, et al. Antimicrob Agents Chemother. 2010 Jun;54(6):2560-6. doi: 10.1128/AAC.01689-09. Epub 2010 Apr 12. Antimicrob Agents Chemother. 2010. PMID: 20385870 Free PMC article. Clinical Trial.
1,610 results