Starosta AL - Search Results

1

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis.

Jenner L, Starosta AL, Terry DS, Mikolajka A, Filonava L, Yusupov M, Blanchard SC, Wilson DN, Yusupova G. Jenner L, et al. Among authors: starosta al. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3812-6. doi: 10.1073/pnas.1216691110. Epub 2013 Feb 19. Proc Natl Acad Sci U S A. 2013. PMID: 23431179 Free PMC article.

2

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning.

Wilson DN, Schluenzen F, Harms JM, Starosta AL, Connell SR, Fucini P. Wilson DN, et al. Among authors: starosta al. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13339-44. doi: 10.1073/pnas.0804276105. Epub 2008 Aug 29. Proc Natl Acad Sci U S A. 2008. PMID: 18757750 Free PMC article.

3

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.

Polikanov YS, Starosta AL, Juette MF, Altman RB, Terry DS, Lu W, Burnett BJ, Dinos G, Reynolds KA, Blanchard SC, Steitz TA, Wilson DN. Polikanov YS, et al. Among authors: starosta al. Mol Cell. 2015 Jun 4;58(5):832-44. doi: 10.1016/j.molcel.2015.04.014. Epub 2015 May 28. Mol Cell. 2015. PMID: 26028538 Free PMC article.

4

Interplay between the ribosomal tunnel, nascent chain, and macrolides influences drug inhibition.

Starosta AL, Karpenko VV, Shishkina AV, Mikolajka A, Sumbatyan NV, Schluenzen F, Korshunova GA, Bogdanov AA, Wilson DN. Starosta AL, et al. Chem Biol. 2010 May 28;17(5):504-14. doi: 10.1016/j.chembiol.2010.04.008. Chem Biol. 2010. PMID: 20534348

5

Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites.

Ratje AH, Loerke J, Mikolajka A, Brünner M, Hildebrand PW, Starosta AL, Dönhöfer A, Connell SR, Fucini P, Mielke T, Whitford PC, Onuchic JN, Yu Y, Sanbonmatsu KY, Hartmann RK, Penczek PA, Wilson DN, Spahn CM. Ratje AH, et al. Among authors: starosta al. Nature. 2010 Dec 2;468(7324):713-6. doi: 10.1038/nature09547. Nature. 2010. PMID: 21124459 Free PMC article.

6

Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.

Grossman TH, Starosta AL, Fyfe C, O'Brien W, Rothstein DM, Mikolajka A, Wilson DN, Sutcliffe JA. Grossman TH, et al. Among authors: starosta al. Antimicrob Agents Chemother. 2012 May;56(5):2559-64. doi: 10.1128/AAC.06187-11. Epub 2012 Feb 21. Antimicrob Agents Chemother. 2012. PMID: 22354310 Free PMC article.

7

Nascent peptides that block protein synthesis in bacteria.

Woolstenhulme CJ, Parajuli S, Healey DW, Valverde DP, Petersen EN, Starosta AL, Guydosh NR, Johnson WE, Wilson DN, Buskirk AR. Woolstenhulme CJ, et al. Among authors: starosta al. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E878-87. doi: 10.1073/pnas.1219536110. Epub 2013 Feb 19. Proc Natl Acad Sci U S A. 2013. PMID: 23431150 Free PMC article.

8

Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P.

Peil L, Starosta AL, Lassak J, Atkinson GC, Virumäe K, Spitzer M, Tenson T, Jung K, Remme J, Wilson DN. Peil L, et al. Among authors: starosta al. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15265-70. doi: 10.1073/pnas.1310642110. Epub 2013 Sep 3. Proc Natl Acad Sci U S A. 2013. PMID: 24003132 Free PMC article.

9

Ribosome rescue, nearing the end.

Starosta AL, Wilson DN. Starosta AL, et al. Cell. 2014 Feb 27;156(5):866-7. doi: 10.1016/j.cell.2014.02.028. Cell. 2014. PMID: 24581485 Free article.

10

The bacterial translation stress response.

Starosta AL, Lassak J, Jung K, Wilson DN. Starosta AL, et al. FEMS Microbiol Rev. 2014 Nov;38(6):1172-201. doi: 10.1111/1574-6976.12083. Epub 2014 Sep 26. FEMS Microbiol Rev. 2014. PMID: 25135187 Free PMC article. Review.

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