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Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA. Tannahill GM, et al. Among authors: kelly b, kelly vp. Nature. 2013 Apr 11;496(7444):238-42. doi: 10.1038/nature11986. Epub 2013 Mar 24. Nature. 2013. PMID: 23535595 Free PMC article.
Malonylation of GAPDH is an inflammatory signal in macrophages.
Galván-Peña S, Carroll RG, Newman C, Hinchy EC, Palsson-McDermott E, Robinson EK, Covarrubias S, Nadin A, James AM, Haneklaus M, Carpenter S, Kelly VP, Murphy MP, Modis LK, O'Neill LA. Galván-Peña S, et al. Among authors: kelly vp. Nat Commun. 2019 Jan 18;10(1):338. doi: 10.1038/s41467-018-08187-6. Nat Commun. 2019. PMID: 30659183 Free PMC article.
Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver.
van Wijk K, Akabane T, Kimura T, Saitoh S, Okano S, Kelly VP, Takagi M, Kodama K, Takahashi K, Tanaka T, Nakajima M, Nakajima O. van Wijk K, et al. Among authors: kelly vp. Arch Biochem Biophys. 2021 Jan 15;697:108721. doi: 10.1016/j.abb.2020.108721. Epub 2020 Dec 8. Arch Biochem Biophys. 2021. PMID: 33307066 Free article.
5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice.
Saitoh S, Okano S, Nohara H, Nakano H, Shirasawa N, Naito A, Yamamoto M, Kelly VP, Takahashi K, Tanaka T, Nakajima M, Nakajima O. Saitoh S, et al. Among authors: kelly vp. PLoS One. 2018 Jan 24;13(1):e0189593. doi: 10.1371/journal.pone.0189593. eCollection 2018. PLoS One. 2018. PMID: 29364890 Free PMC article.
TRMT2A is a novel cell cycle regulator that suppresses cell proliferation.
Chang YH, Nishimura S, Oishi H, Kelly VP, Kuno A, Takahashi S. Chang YH, et al. Among authors: kelly vp. Biochem Biophys Res Commun. 2019 Jan 8;508(2):410-415. doi: 10.1016/j.bbrc.2018.11.104. Epub 2018 Nov 28. Biochem Biophys Res Commun. 2019. PMID: 30502085 Free article.
49 results