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p38 inhibition and not MK2 inhibition enhances the secretion of chemokines from TNF-α activated rheumatoid arthritis fibroblast-like synoviocytes.
Dulos J, Wijnands FP, van den Hurk-van Alebeek JA, van Vugt MJ, Rullmann JA, Schot JJ, de Groot MW, Wagenaars JL, van Ravestein-van Os R, Smets RL, Vink PM, Hofstra CL, Nelissen RL, van Eenennaam H. Dulos J, et al. Among authors: nelissen rl. Clin Exp Rheumatol. 2013 Jul-Aug;31(4):515-25. Epub 2013 Apr 3. Clin Exp Rheumatol. 2013. PMID: 23558031
A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha.
Mihara K, Almansa C, Smeets RL, Loomans EE, Dulos J, Vink PM, Rooseboom M, Kreutzer H, Cavalcanti F, Boots AM, Nelissen RL. Mihara K, et al. Among authors: nelissen rl. Br J Pharmacol. 2008 May;154(1):153-64. doi: 10.1038/bjp.2008.53. Epub 2008 Feb 25. Br J Pharmacol. 2008. PMID: 18297096 Free PMC article.
The early clinical course of infliximab treatment in rheumatoid arthritis: results from the REMARK observational study.
Westhovens R, van Vollenhoven RF, Boumpas DT, Brzosko M, Svensson K, Bjorneboe O, Meeuwisse CM, Srinivasan S, Gaudin P, Smolen JS, Rahman MU, Nelissen RL, Vastesaeger N. Westhovens R, et al. Among authors: nelissen rl. Clin Exp Rheumatol. 2014 May-Jun;32(3):315-23. Epub 2014 Feb 11. Clin Exp Rheumatol. 2014. PMID: 24529163 Clinical Trial.
16 results