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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.
J Med Chem. 2013 Jul 11;56(13):5261-74. doi: 10.1021/jm301741t. Epub 2013 Jun 20.
J Med Chem. 2013.
PMID: 23713656
Pharmacological inhibition of polo like kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei.
Fitzgerald K, Bergeron M, Willits C, Bowers S, Aubele DL, Goldbach E, Tonn G, Ness D, Olaharski A.
Fitzgerald K, et al. Among authors: willits c.
Toxicol Appl Pharmacol. 2013 May 15;269(1):1-7. doi: 10.1016/j.taap.2013.02.012. Epub 2013 Mar 1.
Toxicol Appl Pharmacol. 2013.
PMID: 23466428
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Development of ALZET® osmotic pump compatible solvent compositions to solubilize poorly soluble compounds for preclinical studies.
Gullapalli R, Wong A, Brigham E, Kwong G, Wadsworth A, Willits C, Quinn K, Goldbach E, Samant B.
Gullapalli R, et al. Among authors: willits c.
Drug Deliv. 2012 Jun-Jul;19(5):239-46. doi: 10.3109/10717544.2012.691121. Epub 2012 Jun 1.
Drug Deliv. 2012.
PMID: 22656673
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Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS.
Flanagan K, Fitzgerald K, Baker J, Regnstrom K, Gardai S, Bard F, Mocci S, Seto P, You M, Larochelle C, Prat A, Chow S, Li L, Vandevert C, Zago W, Lorenzana C, Nishioka C, Hoffman J, Botelho R, Willits C, Tanaka K, Johnston J, Yednock T.
Flanagan K, et al. Among authors: willits c.
PLoS One. 2012;7(7):e40443. doi: 10.1371/journal.pone.0040443. Epub 2012 Jul 6.
PLoS One. 2012.
PMID: 22792325
Free PMC article.
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Maple sirup. XIII. Sterilizing effect of sunlight on maple sap in transparent tubes.
FRANK HA, WILLITS CO.
FRANK HA, et al. Among authors: willits co.
Appl Microbiol. 1960 May;8(3):141-5. doi: 10.1128/am.8.3.141-145.1960.
Appl Microbiol. 1960.
PMID: 13824505
Free PMC article.
No abstract available.
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Maple sirup. XII. Effect of zinc on the growth of microorganisms in maple sap.
FRANK HA, NAGHSKI J, REED LL, WILLITS CO.
FRANK HA, et al. Among authors: willits co.
Appl Microbiol. 1959 May;7(3):152-5. doi: 10.1128/am.7.3.152-155.1959.
Appl Microbiol. 1959.
PMID: 13650519
Free PMC article.
No abstract available.
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Maple syrup. IX. Microorganisms as a cause of premature stoppage of sap flow from maple tap holes.
NAGHSKI J, WILLITS CO.
NAGHSKI J, et al. Among authors: willits co.
Appl Microbiol. 1955 May;3(3):149-51. doi: 10.1128/am.3.3.149-151.1955.
Appl Microbiol. 1955.
PMID: 14377381
Free PMC article.
No abstract available.
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