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Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P. Al-Hasani K, et al. Among authors: leuckx g. Dev Cell. 2013 Jul 15;26(1):86-100. doi: 10.1016/j.devcel.2013.05.018. Epub 2013 Jun 27. Dev Cell. 2013. PMID: 23810513 Free article.
The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells.
Courtney M, Gjernes E, Druelle N, Ravaud C, Vieira A, Ben-Othman N, Pfeifer A, Avolio F, Leuckx G, Lacas-Gervais S, Burel-Vandenbos F, Ambrosetti D, Hecksher-Sorensen J, Ravassard P, Heimberg H, Mansouri A, Collombat P. Courtney M, et al. Among authors: leuckx g. PLoS Genet. 2013 Oct;9(10):e1003934. doi: 10.1371/journal.pgen.1003934. Epub 2013 Oct 31. PLoS Genet. 2013. PMID: 24204325 Free PMC article.
Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis.
Ben-Othman N, Vieira A, Courtney M, Record F, Gjernes E, Avolio F, Hadzic B, Druelle N, Napolitano T, Navarro-Sanz S, Silvano S, Al-Hasani K, Pfeifer A, Lacas-Gervais S, Leuckx G, Marroquí L, Thévenet J, Madsen OD, Eizirik DL, Heimberg H, Kerr-Conte J, Pattou F, Mansouri A, Collombat P. Ben-Othman N, et al. Among authors: leuckx g. Cell. 2017 Jan 12;168(1-2):73-85.e11. doi: 10.1016/j.cell.2016.11.002. Epub 2016 Dec 1. Cell. 2017. PMID: 27916274 Free article.
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.
Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H. Baeyens L, et al. Among authors: leuckx g. Nat Biotechnol. 2014 Jan;32(1):76-83. doi: 10.1038/nbt.2747. Epub 2013 Nov 17. Nat Biotechnol. 2014. PMID: 24240391 Free PMC article. Retracted.
Partial duct ligation: β-cell proliferation and beyond.
Van de Casteele M, Leuckx G, Cai Y, Yuchi Y, Coppens V, De Groef S, Van Gassen N, Baeyens L, Heremans Y, Wright CV, Heimberg H. Van de Casteele M, et al. Among authors: leuckx g. Diabetes. 2014 Aug;63(8):2567-77. doi: 10.2337/db13-0831. Diabetes. 2014. PMID: 25060885 No abstract available.
The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling.
Sojoodi M, Stradiot L, Tanaka K, Heremans Y, Leuckx G, Besson V, Staels W, Van de Casteele M, Marazzi G, Sassoon D, Heimberg H, Bonfanti P. Sojoodi M, et al. Among authors: leuckx g. Diabetologia. 2016 Jul;59(7):1474-1479. doi: 10.1007/s00125-016-3954-z. Epub 2016 Apr 29. Diabetologia. 2016. PMID: 27130279 Free PMC article.
31 results