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A multi-centre phase I trial of the PARP inhibitor olaparib in patients with relapsed chronic lymphocytic leukaemia, T-prolymphocytic leukaemia or mantle cell lymphoma.
Pratt G, Yap C, Oldreive C, Slade D, Bishop R, Griffiths M, Dyer MJS, Fegan C, Oscier D, Pettitt A, Matutes E, Devereux S, Allsup D, Bloor A, Hillmen P, Follows G, Rule S, Moss P, Stankovic T. Pratt G, et al. Among authors: yap c. Br J Haematol. 2018 Aug;182(3):429-433. doi: 10.1111/bjh.14793. Epub 2017 Jun 23. Br J Haematol. 2018. PMID: 28643365 Free article. Clinical Trial. No abstract available.
Implementing the EffTox dose-finding design in the Matchpoint trial.
Brock K, Billingham L, Copland M, Siddique S, Sirovica M, Yap C. Brock K, et al. Among authors: yap c. BMC Med Res Methodol. 2017 Jul 20;17(1):112. doi: 10.1186/s12874-017-0381-x. BMC Med Res Methodol. 2017. PMID: 28728594 Free PMC article. Clinical Trial.
Adaptive designs in clinical trials: why use them, and how to run and report them.
Pallmann P, Bedding AW, Choodari-Oskooei B, Dimairo M, Flight L, Hampson LV, Holmes J, Mander AP, Odondi L, Sydes MR, Villar SS, Wason JMS, Weir CJ, Wheeler GM, Yap C, Jaki T. Pallmann P, et al. Among authors: yap c. BMC Med. 2018 Feb 28;16(1):29. doi: 10.1186/s12916-018-1017-7. BMC Med. 2018. PMID: 29490655 Free PMC article.
How to design a dose-finding study using the continual reassessment method.
Wheeler GM, Mander AP, Bedding A, Brock K, Cornelius V, Grieve AP, Jaki T, Love SB, Odondi L, Weir CJ, Yap C, Bond SJ. Wheeler GM, et al. Among authors: yap c. BMC Med Res Methodol. 2019 Jan 18;19(1):18. doi: 10.1186/s12874-018-0638-z. BMC Med Res Methodol. 2019. PMID: 30658575 Free PMC article.
Lenalidomide, dexamethasone and alemtuzumab or ofatumumab in high-risk chronic lymphocytic leukaemia: final results of the NCRI CLL210 trial.
Pettitt AR, Jackson R, Cicconi S, Polydoros F, Yap C, Dodd J, Bickerstaff M, Stackpoole M, Khan UT, Carruthers S, Oates M, Lin K, Coupland SE, Menon G, Kalakonda N, McCarthy H, Bloor A, Schuh A, Duncombe A, Dearden C, Fegan C, Kennedy B, Walewska R, Marshall S, Fox CP, Hillmen P. Pettitt AR, et al. Among authors: yap c. Haematologica. 2020 Dec 1;105(12):2868-2871. doi: 10.3324/haematol.2019.230805. Haematologica. 2020. PMID: 33256390 Free PMC article. No abstract available.
Embracing model-based designs for dose-finding trials.
Love SB, Brown S, Weir CJ, Harbron C, Yap C, Gaschler-Markefski B, Matcham J, Caffrey L, McKevitt C, Clive S, Craddock C, Spicer J, Cornelius V. Love SB, et al. Among authors: yap c. Br J Cancer. 2017 Jul 25;117(3):332-339. doi: 10.1038/bjc.2017.186. Epub 2017 Jun 29. Br J Cancer. 2017. PMID: 28664918 Free PMC article. Review.
Adaptive trial designs: what are multiarm, multistage trials?
Millen GC, Yap C. Millen GC, et al. Among authors: yap c. Arch Dis Child Educ Pract Ed. 2020 Dec;105(6):376-378. doi: 10.1136/archdischild-2019-317826. Epub 2019 Oct 29. Arch Dis Child Educ Pract Ed. 2020. PMID: 31662314 No abstract available.
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