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CaMKII is essential for the proasthmatic effects of oxidation.
Sanders PN, Koval OM, Jaffer OA, Prasad AM, Businga TR, Scott JA, Hayden PJ, Luczak ED, Dickey DD, Allamargot C, Olivier AK, Meyerholz DK, Robison AJ, Winder DG, Blackwell TS, Dworski R, Sammut D, Wagner BA, Buettner GR, Pope RM, Miller FJ Jr, Dibbern ME, Haitchi HM, Mohler PJ, Howarth PH, Zabner J, Kline JN, Grumbach IM, Anderson ME. Sanders PN, et al. Among authors: grumbach im. Sci Transl Med. 2013 Jul 24;5(195):195ra97. doi: 10.1126/scitranslmed.3006135. Sci Transl Med. 2013. PMID: 23884469 Free PMC article.
Calmodulin kinase II is required for fight or flight sinoatrial node physiology.
Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Wu Y, et al. Among authors: grumbach im. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5972-7. doi: 10.1073/pnas.0806422106. Epub 2009 Mar 10. Proc Natl Acad Sci U S A. 2009. PMID: 19276108 Free PMC article.
CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations.
Koval OM, Guan X, Wu Y, Joiner ML, Gao Z, Chen B, Grumbach IM, Luczak ED, Colbran RJ, Song LS, Hund TJ, Mohler PJ, Anderson ME. Koval OM, et al. Among authors: grumbach im. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4996-5000. doi: 10.1073/pnas.0913760107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194790 Free PMC article.
The multifunctional Ca2+/calmodulin-dependent kinase II delta (CaMKIIdelta) controls neointima formation after carotid ligation and vascular smooth muscle cell proliferation through cell cycle regulation by p21.
Li W, Li H, Sanders PN, Mohler PJ, Backs J, Olson EN, Anderson ME, Grumbach IM. Li W, et al. Among authors: grumbach im. J Biol Chem. 2011 Mar 11;286(10):7990-7999. doi: 10.1074/jbc.M110.163006. Epub 2010 Dec 30. J Biol Chem. 2011. PMID: 21193397 Free PMC article.
CaMKII in the cardiovascular system: sensing redox states.
Erickson JR, He BJ, Grumbach IM, Anderson ME. Erickson JR, et al. Among authors: grumbach im. Physiol Rev. 2011 Jul;91(3):889-915. doi: 10.1152/physrev.00018.2010. Physiol Rev. 2011. PMID: 21742790 Free PMC article. Review.
Oxidized CaMKII causes cardiac sinus node dysfunction in mice.
Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He BJ, Luczak ED, Joiner ML, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov I, Dobrev D, Mohler PJ, Hund TJ, Anderson ME. Swaminathan PD, et al. Among authors: grumbach im. J Clin Invest. 2011 Aug;121(8):3277-88. doi: 10.1172/JCI57833. Epub 2011 Jul 25. J Clin Invest. 2011. PMID: 21785215 Free PMC article.
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
He BJ, Joiner ML, Singh MV, Luczak ED, Swaminathan PD, Koval OM, Kutschke W, Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR, Sigmund CD, Blankesteijn WM, Heymans S, Mohler PJ, Anderson ME. He BJ, et al. Among authors: grumbach im. Nat Med. 2011 Nov 13;17(12):1610-8. doi: 10.1038/nm.2506. Nat Med. 2011. PMID: 22081025 Free PMC article.
Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension.
Xie YP, Chen B, Sanders P, Guo A, Li Y, Zimmerman K, Wang LC, Weiss RM, Grumbach IM, Anderson ME, Song LS. Xie YP, et al. Among authors: grumbach im. Hypertension. 2012 Feb;59(2):355-62. doi: 10.1161/HYPERTENSIONAHA.111.180968. Epub 2011 Dec 27. Hypertension. 2012. PMID: 22203744 Free PMC article.
The multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9.
Scott JA, Xie L, Li H, Li W, He JB, Sanders PN, Carter AB, Backs J, Anderson ME, Grumbach IM. Scott JA, et al. Among authors: grumbach im. Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H1953-64. doi: 10.1152/ajpheart.00978.2011. Epub 2012 Mar 16. Am J Physiol Heart Circ Physiol. 2012. PMID: 22427508 Free PMC article.
83 results